Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Conjugates of metallacarboranes and short cationic peptides with antibacterial and anticancer activity.

2019/32/C/NZ7/00510

Keywords:

boron clusters metallacarboranes antimicrobial peptides anticancer peptides conjugates

Descriptors:

  • NZ7_016:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Krzysztof Konrad Fink 

Number of co-investigators in the project: 7

Call: SONATINA 3 - announced on 2018-12-14

Amount awarded: 995 254 PLN

Project start date (Y-m-d): 2019-12-16

Project end date (Y-m-d): 2023-10-15

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Boron cluster compounds as new chemical leads for antimicrobial therapy
    Authors:
    Krzysztof Fink, Mariusz Uchman
    Academic press:
    Coordination Chemistry Reviews (rok: 2021, tom: 431, strony: 213684), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2020.213684 - link to the publication
  2. Supramolecular chemistry of anionic boron clusters and its applications in biology
    Authors:
    Jakub Cebula, Krzysztof Fink, Janusz Boratyński, Tomasz M. Goszczyński
    Academic press:
    Coordination Chemistry Reviews (rok: 2023, tom: 477, strony: 214940), Wydawca: Science Direct
    Status:
    Published
    DOI:
    10.1016/j.ccr.2022.214940 - link to the publication
  3. Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore
    Authors:
    Krzysztof Fink, Jakub Cebula, Zdeněk Tošner, Mateusz Psurski, Mariusz Uchman, Tomasz M. Goszczyński
    Academic press:
    Dalton Transactions (rok: 2023, tom: 52, strony: 10338-10347), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D3DT01836A - link to the publication
  4. Structural Patterns Enhancing the Antibacterial Activity of Metallacarborane-Based Antibiotics
    Authors:
    Jakub Cebula Jakub Cebula Laboratory of Biomedical Chemistry, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland More by Jakub Cebula , Krzysztof Fink, Waldemar Goldeman, Bożena Szermer-Olearnik, Anna Nasulewicz-Goldeman, Mateusz Psurski, Monika Cuprych, Anna Kędziora, Bartłomiej Dudek, Gabriela Bugla-Płoskońska, Monika Chaszczewska-Markowska, Michalina Gos, Paweł Migdał, and Tomasz M. Goszczyński
    Academic press:
    Journal of Medicinal Chemistry (rok: 2023, tom: 66, strony: 14948-14962), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.3c01516 - link to the publication

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