Projects funded by the NCN

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Information of the project and the call

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Searching for effective strategies to protect neuronal cells against hypoxia and ischemia: Identification of neuroprotective mechanisms of the new ligands of AhR and PPARg in experimental models of stroke.

2018/31/B/NZ7/01815

Keywords:

neuroprotection hypoxia ischemia stroke apoptosis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_5: Molecular neurobiology
  • NZ3_3: Apoptosis

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Kajta 

Number of co-investigators in the project: 5

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 362 200 PLN

Project start date (Y-m-d): 2019-06-28

Project end date (Y-m-d): 2023-06-27

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes
    Authors:
    Rzemieniec J, Bratek E, Wnuk A, Przepiórska K, Salińska E, Kajta M
    Academic press:
    Apoptosis (rok: 2020, tom: 25 (9-10), strony: 747-762), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-020-01631-3 - link to the publication
  2. Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation
    Authors:
    Przepiórska K, Wnuk A, Beyer C, Kajta M.
    Academic press:
    Molecular Neurobiology (rok: 2023, tom: 60, strony: 576-595), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-022-03087-9 - link to the publication
  3. Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia
    Authors:
    Wnuk A, Przepiórska K, Pietrzak BA, Kajta M.
    Academic press:
    Biomedicines (rok: 2021, tom: 9, 854, strony: 45682), Wydawca: MDPI Academic Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/biomedicines9080854 - link to the publication

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