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Identyfication of the epigenetic modulation mechanisms of SOX genes and their transcripts as a potential diagnostic markers in non-small cell lung carcinomas (NSCLC).

2018/31/B/NZ5/02238

Keywords:

SOX SOX18 SOX30 non-small cell lung cancer lung adenocarcinoma sqamous cell lung cancer miRNA methylation

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ5_1: Etiology of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Piotr Dzięgiel 

Number of co-investigators in the project: 7

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 974 560 PLN

Project start date (Y-m-d): 2019-07-01

Project end date (Y-m-d): 2024-06-30

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Current Landscape of Non-Small Cell Lung Cancer: Epidemiology, Histological Classification, Targeted Therapies, and Immunotherapy
    Authors:
    Olga Rodak, Manuel David Peris-Díaz, Mateusz Olbromski, Marzenna Podhorska-Okołów, Piotr Dzięgiel
    Academic press:
    Cancers (rok: 2021, tom: 13(18), 4705, strony: 12055), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13184705 - link to the publication
  2. Role of SOX Protein Groups F and H in Lung Cancer Progression
    Authors:
    Mateusz Olbromski, Marzenna Podhorska-Okołów, Piotr Dzięgiel
    Academic press:
    Cancers (rok: 2020, tom: 3;12(11):3235., strony: 45315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12113235 - link to the publication
  3. argeting SOX18 Transcription Factor Activity by Small-Molecule Inhibitor Sm4 in Non-Small Lung Cancer Cell Lines
    Authors:
    Olga Rodak, Monika Mrozowska, Agnieszka Rusak, Agnieszka Gomułkiewicz, Aleksandra Piotrowska , Mateusz Olbromski, Marzenna Podhorska-Okołów, Maciej Ugorski, Piotr Dzi˛egiel
    Academic press:
    International Journal of Cancer Research (rok: 2023, tom: 24, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241411316 - link to the publication

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