Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Multi-level molecular assessment based on laser microdissection of corneas to reveal biomarkers and therapeutic targets of keratoconus

2018/31/B/NZ5/03280

Keywords:

keratoconus laser microdissection RNA-Seq WES proteome metabolome

Descriptors:

  • NZ5_1:
  • NZ5_3:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marzena Magdalena Gajęcka 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 2 357 488 PLN

Project start date (Y-m-d): 2019-07-24

Project end date (Y-m-d): 2024-07-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (9)
  • Book publications / chapters in book publications (1)
  1. The Impaired Wound Healing Process Is a Major Factor in Remodeling of the Corneal Epithelium in Adult and Adolescent Patients With Keratoconus
    Authors:
    Jaskiewicz K, Maleszka-Kurpiel M, Matuszewska E, Kabza M, Rydzanicz M, Malinowski R, Ploski R, Matysiak J, Gajecka M.
    Academic press:
    Investigative Ophthalmology & Visual Science [Q1 in Ophthalmology, ranked by Journal Impact Factor (source: Web of Science, 2023] (rok: 2023, tom: 64(2), strony: 46041), Wydawca: The Association for Research in Vision and Ophthalmology
    Status:
    Published
    DOI:
    10.1167/iovs.64.2.22 - link to the publication
  2. Accumulation of sequence variants in genes of Wnt signaling and focal adhesion pathways in human corneas further explains their involvement in keratoconus
    Authors:
    Justyna A. Karolak, Tomasz Gambin, Malgorzata Rydzanicz, Piotr Polakowski, Rafal Ploski, Jacek P. Szaflik and Marzena Gajecka
    Academic press:
    PeerJ - Life & Environment [Q1 in Multidisciplinary Sciences, ranked by Journal Impact Factor (source: Web of Science, 2023)] (rok: 2020, tom: 8, strony: 8:e8982), Wydawca: PeerJ Inc.
    Status:
    Published
    DOI:
    10.7717/peerj.8982 - link to the publication
  3. Sequence variants contributing to dysregulated inflammatory responses across keratoconic cone surface in adolescent patients with keratoconus
    Authors:
    Jaskiewicz K., Maleszka-Kurpiel M., Kabza M., Karolak J.A., Gajecka M.
    Academic press:
    Frontiers in Immunology [Q1 in Immunology, ranked by Journal Impact Factor (source: Web of Science, 2023)] (rok: 2023, tom: 14:1197054, strony: 46035), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1197054 - link to the publication
  4. Further evaluation of differential expression of keratoconus candidate genes in human corneas
    Authors:
    Justyna A. Karolak, Barbara Ginter-Matuszewska, Katarzyna Tomela, Michal Kabza, Dorota M. Nowak-Malczewska, Malgorzata Rydzanicz, Piotr Polakowski, Jacek P. Szaflik and Marzena Gajecka
    Academic press:
    PeerJ - Life & Environment [Q1 in Multidisciplinary Sciences, ranked by Journal Impact Factor (source: Web of Science, 2023)] (rok: 2020, tom: 8, strony: 8:e9793), Wydawca: PeerJ Inc.
    Status:
    Published
    DOI:
    10.7717/peerj.9793 - link to the publication
  5. Differentially expressed microRNAs targeting genes in key pathways in keratoconus
    Authors:
    Nowak-Malczewska D.M., Swierkowska J., Gajecka M.
    Academic press:
    Frontiers in Genetics [Q2 in GENETICS & HEREDITY, ranked by Journal Impact Factor (source: Web of Science, 2023)] (rok: 2024, tom: 15:1301676, strony: 46031), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fgene.2024.1301676 - link to the publication
  6. Non-allergic eye rubbing is a major behavioral risk factor for keratoconus
    Authors:
    Katarzyna Jaskiewicz, Magdalena Maleszka-Kurpiel, Andrzej Michalski, Rafal Ploski, Malgorzata Rydzanicz, Marzena Gajecka
    Academic press:
    PLOS One [Q1 in Multidisciplinary Sciences, ranked by Journal Citation Indicator (source: Web of Science, 2023)] (rok: 2023, tom: 18(4): e0284454, strony: 46043), Wydawca: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0284454 - link to the publication
  7. Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4
    Authors:
    Katarzyna Jaskiewicz-Rajewicz, Alicja Wysocka, Magdalena Maleszka-Kurpiel, Eliza Matuszewska-Mach, Katarzyna Jaskiewicz-Rajewicz, Alicja Wysocka, Magdalena Maleszka-Kurpiel, Eliza Matuszewska-Mach, Jakub Wozniak, Rafal Ploski, Jan Matysiak, Malgorzata Rydzanicz and Marzena Gajecka
    Status:
    Accepted for publication
  1. Signs of corneal wound healing in the corneal epithelium in Keratoconus
    Authors:
    K. Jaskiewicz , M. Maleszka-Kurpiel, M. Rydzanicz, E. Matuszewska, J.A. Karolak, J. Matysiak, R. Ploski , M. Gajecka
    Conference:
    6th Polish Congress of Genetics, Kraków 2022 (rok: 2022, ), Wydawca: Polish Society of Genetics
    Data:
    konferencja 27-30.06.2022
    Status:
    Published
  2. Characteristics of keratoconus corneal epithelium in multi-omic approach
    Authors:
    Jaskiewicz K, Maleszka-Kurpiel M, Rydzanicz M, Matuszewska E, Matysiak J, Ploski R, Gajecka M.
    Conference:
    American Society of Human Genetics 71st Annual Meeting; ASHG Virtual Meeting 2021 (rok: 2021, ), Wydawca: American Journal of Human Genetics
    Data:
    konferencja 18-22.10.2021
    Status:
    Published
  3. Structural variation in Keratoconus
    Authors:
    M. Rydzanicz, A. Wysocka, K. Jaskiewicz, M. Maleszka-Kurpiel, M. Kabza, M. Gajecka
    Conference:
    75th Annual Meeting of the American Society of Human Genetics 2023 (rok: 2023, ), Wydawca: American Society of Human Genetics
    Data:
    konferencja November 1 – 5, 2023
    Status:
    Published
  4. Cone-related transcriptomic profiles in Keratoconus corneal epithelium
    Authors:
    K. Jaskiewicz, M. Maleszka-Kurpiel, M. Rydzanicz, Karolak JA, R. Ploski, M. Gajecka
    Conference:
    54th European Human Genetics Conference; European Human Genetics Virtual Conference 2021 (rok: 2021, ), Wydawca: European Journal of Human Genetics
    Data:
    konferencja 28-31.08.2021
    Status:
    Published
  5. Transcriptomic profiles of corneal epithelium reflect irregularities in epithelial thickness maps of post-refractive ectasia patients
    Authors:
    K. Jaskiewicz, M. Maleszka-Kurpiel, M. Kabza4, R. Ploski, M. Rydzanicz, M. Gajecka
    Conference:
    75th Annual Meeting of the American Society of Human Genetics 2023 (rok: 2023, ), Wydawca: American Society of Human Genetics
    Data:
    konferencja November 1 – 5, 2023
    Status:
    Published
  6. Coding and non-coding sequence variation across keratoconic cone surface
    Authors:
    M. Gajecka, M. Maleszka-Kurpiel, M. Kabza, J. Karolak, K. Jaskiewicz
    Conference:
    75th Annual Meeting of the American Society of Human Genetics 2023 (rok: 2023, ), Wydawca: American Society of Human Genetic
    Data:
    konferencja November 1 – 5, 2023
    Status:
    Published
  7. How prepare a corneal epithelium for cone-related transcriptomic profile assessment in keratoconus?
    Authors:
    K. Jaskiewicz , M. Maleszka-Kurpiel, M. Rydzanicz , R. Ploski , M. Gajecka
    Conference:
    53rd European Society of Human Genetics Conference; European Human Genetics Virtual Conference 2020 (rok: 2020, ), Wydawca: European Journal of Human Genetics
    Data:
    konferencja 6-9.06.2020
    Status:
    Published
  8. Estrogen and androgen related genes in the corneal epithelium in Keratoconus
    Authors:
    Katarzyna Jaskiewicz, Magdalena Maleszka-Kurpiel, Malgorzata Rydzanicz, Justyna Karolak, Rafał Płoski, Marzena Gajecka;
    Conference:
    55th European Human Genetics Conference 2022 (rok: 2022, ), Wydawca: European Journal of Human Genetics
    Status:
    Accepted for publication
  9. A multi-omic approach to characterize the corneal epithelium in patients with post-refractive ectasia
    Authors:
    Katarzyna Jaskiewicz, Alicja Wysocka, Eliza Matuszewska, Magdalena Maleszka-Kurpiel, Jakub Wozniak, Rafał Płoski, Jan Matysiak, Malgorzata Rydzanicz, Marzena Gajecka
    Conference:
    57th European Human Genetics Conference 2022 (rok: 2024, ), Wydawca: Basingstoke, Hampshire, UK;
    Status:
    Accepted for publication
  1. 24. The Genetics of Keratoconus and Related Diseases
    Authors:
    Katarzyna Jaskiewicz and Marzena Gajecka
    Book:
    Genetic Diseases of the Eye (3rd Edition), editors: Elias Traboulsi, Virginia Utz, and Arif Kha (rok: 2023, tom: nie dotyczy, strony: 24108), Wydawca: Oxford University Press
    Status:
    Accepted for publication

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