Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Characterization of two novel proteases from the human periodontopathogen Tannerella forsythia

2018/31/N/NZ1/02891

Keywords:

Tannerella forsythia periodontitis metalloproteases endothelin-converting enzyme immunoglobulins A

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology
  • NZ1_10: Microbiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Irena Waligórska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 16 - announced on 2018-09-14

Amount awarded: 139 485 PLN

Project start date (Y-m-d): 2019-08-07

Project end date (Y-m-d): 2022-08-06

Project duration:: 24 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Periodontopathogens interfere with the human renin-angiotensin system through a surface-attached protease
    Authors:
    Irena Waligorska, Krzysztof Zak, Joanna Budziaszek, Ewa Bielecka, Tomasz Kantyka, Joanna Koziel, Ida Thogersen, Jan Enghild, Przemyslaw Grudnik, Jan Potempa, Miroslaw Ksiazek
    Academic press:
    bioRxiv (rok: 2024, tom: brak, strony: 45680), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2024.06.20.599981 - link to the publication
  2. Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia
    Authors:
    Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M.
    Academic press:
    Journal of enzyme inhibition and medicinal chemistry (rok: 2021, tom: 36, strony: 1267–1281), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2021.1937619 - link to the publication
  3. Periodontopathogens impairs the human renin–angiotensin system through surface-attached proteases
    Authors:
    Irena Waligórska, Krzysztof Żak, Natalia Mikrut, Joanna Budziaszek, Ewa Bielecka, Tomasz Kantyka, Joanna Kozieł, Ida B. Thøgersen, Jan J. Enghild, Przemysław Grudnik, Jan Potempa, Mirosław Książek
    Academic press:
    The Proceedings of the National Academy of Sciences (PNAS) (rok: 2024, tom: -, strony: -), Wydawca: National Academy of Sciences (NAS)
    Status:
    Submitted
    DOI:
    brak - link to the publication

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