Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The study of the interaction between the siloxanes (silicones) and the human skin structure as well as evaluation their effects.

2018/31/B/NZ7/02801

Keywords:

skin barrier stratum corneum interaction lipid matrix corneocyte diffusion to skin siloxanes silicones

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krystyna Pieńkowska 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 896 760 PLN

Project start date (Y-m-d): 2019-07-26

Project end date (Y-m-d): 2024-07-25

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Evidence of Skin Barrier Damage by Cyclic Siloxanes (Silicones)—Using Digital Holographic Microscopy
    Authors:
    Krystyna Mojsiewicz-Pieńkowska, Ewa Stachowska, Dominika Krenczkowska, Dagmara Bazar, Frans Meijer
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, 6375, strony: 45340), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176375 - link to the publication
  2. Development of Safrinium dyes for new applications: fuorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis
    Authors:
    FEDOROWICZ JOANNA, BAZAR DAGMARA, Brankiewicz Wioletta, Kapica Hanna, CIURA KRZESIMIR, Zalewska-Piątek Beata, Piątek Rafał, CAL KRZYSZTOF, MOJSIEWICZ-PIEŃKOWSKA KRYSTYNA, SĄCZEWSKI JAROSŁAW
    Academic press:
    Scientifc Reports (rok: 2022, tom: 12, strony: 45307), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-19262-w - link to the publication
  3. Ex vivo human skin is not a barrier for cyclic siloxanes (cyclic silicones): evidence of diffusion, bioaccumulation, and risk of dermal absorption using a new validated GC-FID procedure
    Authors:
    Krenczkowska Dominika, Mojsiewicz-Pieńkowska Krystyna, Wielgomas Bartosz, Bazar Dagmara, Jankowski Zbigniew
    Academic press:
    Pharmaceutics (rok: 2020, tom: 12, 586, strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12060586 - link to the publication
  4. Comparative study of the percutaneous permeation and bioaccumulation of the controversial cyclic siloxane using frozen-thawed and nonfrozen ex vivo human skin
    Authors:
    Krystyna Mojsiewicz-Pieńkowska, Dominika Krenczkowska, Dagmara Bazar, Bartosz Wielgomas, Krzysztof Cal, Michał Kaliszan
    Academic press:
    Toxicology in vitro (rok: 2022, tom: 82, strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2022.105379 - link to the publication

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