Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Interactions of statins with biological membranes - implications for drug delivery research.

2018/31/B/ST4/00406

Keywords:

statins model biological membranes drug carriers cubosomes

Descriptors:

  • ST4_2: Spectroscopic and spectrometric techniques
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Renata Bilewicz 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 298 900 PLN

Project start date (Y-m-d): 2019-07-04

Project end date (Y-m-d): 2023-01-03

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Podstawa stołu optycznego z izolacją (3 727 PLN)
  2. komputer (4 336 PLN)
  3. Zestaw komputerowy z drukarką (6 636 PLN)
  4. potencjostat (71 790 PLN)
  5. licencja na oprogramowanie (311 PLN)
  6. Spektormetr IR (200 000 PLN)
  7. System oczyszczania powietrza do pomiarów w podczerwieni (43 188 PLN)
  8. drukarka (1 822 PLN)
  9. lodówka (3 533 PLN)
  10. potencjostat (87 376 PLN)
  11. termostat cyrkulacyjny (44 930 PLN)
  12. Bipotencjostat (120 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Incorporation of simvastatin into lipid membranes: Why deliver a statin in form of inclusion complex with hydrophilic cyclodextrin
    Authors:
    Aleksandra Bartkowiak, Dorota Matyszewska, Agata Krzak, Michalina Zaborowska, Marcin Broniatowski, Renata Bilewicz
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 204, strony: 111784), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.111784 - link to the publication
  2. Surface and electrochemical properties of lipid raft model membranes and how they are affected by incorporation of statin
    Authors:
    Michalina Zaborowska, Damian Dziubak, Dorota Matyszewska, Renata Bilewicz
    Academic press:
    Electrochimica Acta (rok: 2021, tom: 386, strony: 138514), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.electacta.2021.138514 - link to the publication
  3. Designing a Useful Lipid Raft Model Membrane for Electrochemical and Surface Analytical Studies
    Authors:
    Michalina Zaborowska, Damian Dziubak, Dorota Matyszewska, Slawomir Sek, Renata Bilewicz
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 5483), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26185483 - link to the publication
  4. Simvastatin Coadministration Modulates the Electrostatically Driven Incorporation of Doxorubicin into Model Lipid and Cell Membranes
    Authors:
    Aleksandra Bartkowiak, Ewa Nazaruk, Ewa Gajda, Marlena Godlewska, Damian Gaweł, Elżbieta Jabłonowska, Renata Bilewicz
    Academic press:
    ACS Biomaterials Science & Engineering (rok: 2022, tom: 8, strony: 4354−4364), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.2c00724 - link to the publication
  5. Structural modifications of lipid membranes exposed to statins – Langmuir monolayer and PM-IRRAS study
    Authors:
    M. Zaborowska, M. Broniatowski, P. Wydro, D. Matyszewska, R. Bilewicz
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 313, strony: 113570), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.113570 - link to the publication
  6. Adjusting the Structure of β-Cyclodextrin to Improve Complexation of Anthraquinone-Derived Drugs
    Authors:
    Agata Krzak, Olga Swiech, Maciej Majdecki, Piotr Garbacz, Paulina Gwardys, Renata Bilewicz
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 7205), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26237205 - link to the publication
  7. Statin Action Targets Lipid Rafts of Cell Membranes: GIXD/PM-IRRAS Investigation of Langmuir Monolayers.
    Authors:
    Michalina Zaborowska, Marcin Broniatowski, Philippe Fontaine, Renata Bilewicz, Dorota Matyszewska
    Academic press:
    Journal of Physical Chemistry B (rok: 2023, tom: 127, strony: 7135−7147), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.3c02574 - link to the publication

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