Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel pharmacological strategies for the treatment of depression

2018/31/B/NZ7/00247

Keywords:

GPR39 zinc antidepressants neurodegeneration depression

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Młyniec 

Number of co-investigators in the project: 4

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 2 075 000 PLN

Project start date (Y-m-d): 2019-07-26

Project end date (Y-m-d): 2024-05-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. GPCR Oligomerization as a Target for Antidepressants: Focus on GPR39
    Authors:
    Katarzyna Mlyniec, Dominika Siodłak, Urszula Doboszewska, Gabriel Nowak
    Academic press:
    Pharmacology & Therapeutics (rok: 2021, tom: 225, strony: 107842), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharmthera.2021.107842 - link to the publication
  2. Interaction between zinc, GPR39, BDNF and neuropeptides in depression
    Authors:
    Katarzyna Mlyniec
    Academic press:
    Current Neuropharmacology (rok: 2021, tom: 19, strony: 2012-2019), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X19666210225153404 - link to the publication
  3. Antidepressant efficacy of monoamine-based drugs in chronic unpredictable stress in mice. A link between the GPR39 zinc receptor and monoaminergic systems in depression and anxiety.
    Authors:
    Siodłak D., Doboszewska U., Nowak G., Wlaź P., Mlyniec K.
    Academic press:
    Neuropharmacology (rok: 2024, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Submitted
  4. Interaction between zinc, the GPR39 zinc receptor and the serotonergic system in depression
    Authors:
    Dominika Siodłak, Gabriel Nowak, Katarzyna Mlyniec
    Academic press:
    Brain Research Bulletin (rok: 2021, tom: 170, strony: 146-154), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.brainresbull.2021.02.003. - link to the publication