Projects funded by the NCN

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Information of the project and the call

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Unravelling the controversial role of palmitoleic acid in the dietary prophylaxis of carbohydrate and lipid homeostasis disorders

2018/31/B/NZ9/02433

Keywords:

palmitoleic acid isomers sea buckthorn metabolic syndrome

Descriptors:

  • NZ9_7: Nutrition and food sciences
  • NZ5_7: Human disease treatment

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Edyta Gendaszewska-Darmach 

Number of co-investigators in the project: 9

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 616 400 PLN

Project start date (Y-m-d): 2019-06-21

Project end date (Y-m-d): 2024-06-20

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (1)
  1. Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs
    Authors:
    Anna Drzazga, Daria Kamińska, Anna Gliszczyńska, Edyta Gendaszewska-Darmach
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 5748), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms22115748 - link to the publication
  2. Targeting Small GTPases and Their Prenylation in Diabetes Mellitus
    Authors:
    Edyta Gendaszewska-Darmach, Malgorzata A Garstka, Katarzyna M Błażewska
    Academic press:
    Journal in Medicinal Chemistry (rok: 2021, tom: 64, strony: 9677–9710), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.1c00410 - link to the publication
  3. Trans-palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different mechanism from the cis isomer
    Authors:
    Eliza Korkus, Marcin Szustak, Rafał Madaj, Arkadiusz Chworoś, Anna Drzazga, Maria Koziołkiewicz, Grzegorz Dąbrowski, Sylwester Czaplicki, Iwona Konopka, Edyta Gendaszewska-Darmach,
    Academic press:
    Food & Function (rok: 2023, tom: 14, strony: 6496-6512), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2FO03412C - link to the publication
  4. Composition of flesh lipids and oleosome yield optimization of selected sea buckthorn (Hippophae rhamnoides L.) cultivars grown in Poland
    Authors:
    Grzegorz Dabrowski, Sylwester Czaplicki, Marcin Szustak, Eliza Cichońska, Edyta Gendaszewska-Darmach, Iwona Konopka
    Academic press:
    Food Chemistry (rok: 2022, tom: 369, strony: 130921), Wydawca: ELSEVIER SCI LTD
    Status:
    Published
    DOI:
    10.1016/j.foodchem.2021.130921 - link to the publication
  5. The insulinotropic activity of oleosomes prepared from various sea buckthorn cultivars in mouse and human pancreatic β cell lines
    Authors:
    Eliza Korkus, Marcin Szustak, Grzegorz Dąbrowski, Sylwester Czaplicki, Sławomir Kadłubowski, Maria Koziołkiewicz, Iwona Konopka, Edyta Gendaszewska-Darmach,
    Academic press:
    NFS Journal (rok: 2023, tom: 31, strony: 142-154), Wydawca: Elsevier GmbH
    Status:
    Published
    DOI:
    10.1016/j.nfs.2023.05.002 - link to the publication
  6. Evaluation of the anti-diabetic activity of sea buckthorn pulp oils prepared with different extraction methods in human islet EndoC-betaH1 cells
    Authors:
    Eliza Korkus, Grzegorz Dabrowski, Marcin Szustak, Sylwester Czaplicki, Rafał Madaj, Arkadiusz Chworoś, Maria Koziołkiewicz, Iwona Konopka, Edyta Gendaszewska-Darmach,
    Academic press:
    NFS Journal (rok: 2022, tom: 27, strony: 54-66), Wydawca: Elsevier GmbH
    Status:
    Published
    DOI:
    10.1016/j.nfs.2022.05.002 - link to the publication
  7. Lysophosphatidylcholines Enriched with cis and trans Palmitoleic Acid Regulate Insulin Secretion via GPR119 Receptor
    Authors:
    Marcin Szustak, Eliza Korkus, Rafał Madaj, Arkadiusz Chworos, Grzegorz Dąbrowski, Sylwester Czaplicki, Erfan Tabandeh, Gabriela Maciejewska, Maria Koziołkiewicz, Iwona Konopka, Anna Gliszczyńska, Edyta Gendaszewska-Darmach
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2024, tom: 15, strony: 197–204), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.3c00263 - link to the publication
  8. The impact of selected xanthophylls on oil hydrolysis by pancreatic lipase: in silico and in vitro studies.
    Authors:
    Grzegorz Dąbrowski, Sylwester Czaplicki, Marcin Szustak, Eliza Korkus, Edyta Gendaszewska-Darmach, Iwona Konopka
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 2731), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-53312-9 - link to the publication
  1. Kwasy tłuszczowe izomerii trans a choroby cywilizacyjne
    Authors:
    Eliza Cichońska, Edyta Gendaszewska-Darmach
    Conference:
    XXV Sesja Naukowa Sekcji Młodej Kadry Naukowej PTTŻ Wrocław (rok: 2020, ), Wydawca: Wydawnictwo Uniwersytetu Przyrodniczego We Wrocławiu
    Data:
    konferencja 20-21.05.2021 r.
    Status:
    Published

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