Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of gut microbiota and permeability in the pathophysiology of schizophrenia - in search of the mechanisms underlying subthreshold inflammatory state and metabolic dysregulation

2018/31/B/NZ5/00527

Keywords:

schizophrenia inflammatory state metabolic dysregulation gut microbiota

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_1: Etiology of human diseases
  • NZ6_4: Bacteriology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Błażej Misiak 

Number of co-investigators in the project: 8

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 067 920 PLN

Project start date (Y-m-d): 2019-07-17

Project end date (Y-m-d): 2023-07-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  • Book publications / chapters in book publications (1)
  1. Profiling gut microbiota signatures associated with the deficit subtype of schizophrenia: Findings from a case-control study
    Authors:
    Krzysztof Kowalski, Paulina Żebrowska-Różańska, Paweł Karpiński, Dorota Kujawa, Łukasz Łaczmański, Jerzy Samochowiec, Magdalena Chęć, Patryk Piotrowski, Błażej Misiak
    Academic press:
    Progress in Neuro-Psychopharmacology and Biological Psychiatry (rok: 2023, tom: 127, strony: 110834), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2023.110834 - link to the publication
  2. Gut microbiota and microbiome in schizophrenia
    Authors:
    Jerzy Samochowiec, Błażej Misiak
    Academic press:
    Current Opinion in Psychiatry (rok: 2021, tom: 34, strony: 503-507), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/YCO.0000000000000733 - link to the publication
  3. The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?
    Authors:
    Błażej Misiak, Igor Łoniewski, Wojciech Marlicz, Dorota Frydecka, Agata Szulc, Leszek Rudzki, Jerzy Samochowiec
    Academic press:
    Progress in Neuro-Psychopharmacology & Biological Psychiatry (rok: 2020, tom: 30, strony: 109951), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2020.109951 - link to the publication
  4. Gut microbiota alterations in stable outpatients with schizophrenia: findings from a case-control study
    Authors:
    Błażej Misiak, Patryk Piotrowski, Agnieszka Cyran, Krzysztof Kowalski, Jerzy Samochowiec, Marcin Jabłoński, Piotr Plichta, Łukasz Łaczmański, Paulina Żebrowska, Dorota Kujawa, Igor Łoniewski, Mariusz Kaczmarczyk
    Academic press:
    Acta Neuropsychiatrica (rok: 2023, tom: 35, strony: 147-155), Wydawca: Cambridge University Press
    Status:
    Published
    DOI:
    10.1017/neu.2022.38 - link to the publication
  5. Associations of gut microbiota alterations with clinical, metabolic, and immune-inflammatory characteristics of chronic schizophrenia
    Authors:
    Błażej Misiak, Edyta Pawlak, Krzysztof Rembacz, Marek Kotas, Paulina Żebrowska-Różańska, Dorota Kujawa, Łukasz Łaczmański, Patryk Piotrowski, Tomasz Bielawski, Jerzy Samochowiec, Agnieszka Samochowiec, Paweł Karpiński
    Academic press:
    Journal of Psychiatric Research (rok: 2024, tom: 171, strony: 152-160), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpsychires.2024.01.036 - link to the publication
  6. Gut microbiota alterations in schizophrenia might be related to stress exposure: Findings from the machine learning analysis
    Authors:
    Paweł Karpiński, Paulina Żebrowska-Różańska, Dorota Kujawa, Łukasz Łaczmański, Jerzy Samochowiec, Marcin Jabłoński, Piotr Plichta, Patryk Piotrowski, Tomasz Bielawski, Błażej Misiak
    Academic press:
    Psychoneuroendocrinology (rok: 2023, tom: 155, strony: 106335), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.psyneuen.2023.106335 - link to the publication
  7. The Self-Evaluation of Negative Symptoms in Differentiating Deficit Schizophrenia: The Comparison of Sensitivity and Specificity with Other Tools
    Authors:
    Jerzy Samochowiec, Marcin Jabłoński, Piotr Plichta, Patryk Piotrowski, Bartłomiej Stańczykiewicz, Tomasz Bielawski, Błażej Misiak
    Academic press:
    Psychopathology (rok: 2023, tom: Nieprzypisany (wersja ahead of print), strony: Nieprzypisane (wersja ahead of print)), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000529244 - link to the publication
  8. Risk factors of deficit and non-deficit schizophrenia: Results from a cross-sectional study
    Authors:
    Agnieszka Cyran, Patryk Piotrowski, Jerzy Samochowiec, Tomasz Grąźlewski, Błażej Misiak
    Academic press:
    Revista de Psiquiatría y Salud Mental (rok: 2022, tom: 15, strony: 223-229), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.rpsmen.2022.05.001 - link to the publication
  9. Assessment of Cardiometabolic Risk Reveals Elevated C-Reactive Protein Levels in Patients with Deficit Schizophrenia after Adjustment for Lifestyle Characteristics
    Authors:
    Agnieszka Cyran, Patryk Piotrowski, Jerzy Samochowiec, Agnieszka Samochowiec, Ernest Tyburski, Łukasz Łaczmański, Błażej Misiak
    Academic press:
    Applied Sciences (rok: 2022, tom: 12, strony: 10915), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app122110915 - link to the publication
  10. The deficit subtype of schizophrenia is associated with a pro-inflammatory phenotype but not with altered levels of zonulin: Findings from a case-control study
    Authors:
    Agnieszka Cyran, Edyta Pawlak, Patryk Piotrowski, Tomasz Bielawski, Jerzy Samochowiec, Ernest Tyburski, Magdalena Chęć, Krzysztof Rembacz, Łukasz Łaczmański, Wiktoria Bieniek, Andrzej Gamian, Błażej Misiak
    Academic press:
    Psychoneuroendocrinology (rok: 2023, tom: 153, strony: 106109), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.psyneuen.2023.106109 - link to the publication
  11. The Deficit Schizophrenia Subtype Is Associated with Low Adherence to the Mediterranean Diet: Findings from a Case-Control Study
    Authors:
    Krzysztof Kowalski, Bogna Bogudzińska, Bartłomiej Stańczykiewicz, Patryk Piotrowski, Tomasz Bielawski, Jerzy Samochowiec, Krzysztof Szczygieł, Piotr Plichta, Błażej Misiak
    Academic press:
    Journal of Clinical Medicine (rok: 2022, tom: 11, strony: 568), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm11030568 - link to the publication
  12. Analysis of Gut Microbiota and Their Metabolic Potential in Patients with Schizophrenia Treated with Olanzapine: Results from a Six-Week Observational Prospective Cohort Study
    Authors:
    Justyna Pełka-Wysiecka, Mariusz Kaczmarczyk, Agata Bąba-Kubiś, Paweł Liśkiewicz, Michał Wroński, Karolina Skonieczna-Żydecka, Wojciech Marlicz, Błażej Misiak, Teresa Starzyńska, Jolanta Kucharska-Mazur, Igor Łoniewski, Jerzy Samochowiec
    Academic press:
    Journal of Clinical Medicine (rok: 2019, tom: 8, strony: 1605), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm8101605 - link to the publication
  1. W poszukiwaniu nowych uwarunkowań zaburzeń psychicznych - rola mikroflory jelitowej
    Authors:
    Błażej Misiak
    Book:
    Kryzys psychiczny we współczesnym świecie (rok: 2021, tom: 1, strony: 43-62), Wydawca: PWN, Instytut Psychologii Polskiej Akademii Nauk
    Status:
    Published