Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Piezolytes and osmolytes in the circulatory system - roles in health and disease.

2018/31/B/NZ5/00038

Keywords:

circulatory system hypertension heart failure piezolytes osmolytes

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ4_4: Pathophysiology
  • NZ4_2: Physiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarsko-Stomatologiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Ufnal 

Number of co-investigators in the project: 8

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 795 600 PLN

Project start date (Y-m-d): 2019-07-04

Project end date (Y-m-d): 2023-01-03

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kołyska do probówek (5 500 PLN)
  2. Western blotting system, kompletny zestawy (97 000 PLN)
  3. Zamrażarka Niskotemperaturowa.
  4. Komora do pracy w warunkach sterylnych (7 500 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats.
    Authors:
    Gawrys-Kopczynska M, Konop M, Maksymiuk K, Kraszewska K, Derzsi L, Sozanski K, Holyst R, Pilz M, Samborowska E, Dobrowolski L, Jaworska K, Mogilnicka I, Ufnal M.
    Academic press:
    Elife (rok: 2020, tom: 8, strony: e57028.), Wydawca: eLife Sciences Publications Ltd
    Status:
    Published
    DOI:
    10.7554/eLife.57028. - link to the publication
  2. Genetically determined hypertensive phenotype affects gutmicrobiota composition, but not vice versa
    Authors:
    Piotr Konopelskia, Marek Konopa, Karol Perlejewskib, Iwona Bukowska-Oskob, Marek Radkowskib, Maksymilian Onyszkiewicza, Kinga Jaworskaa, Izabella Mogilnickaa, Emilia Samborowskac, and Marcin Ufnala
    Academic press:
    Journal of Hypertension (rok: 2021, tom: 39, strony: 790-1799), Wydawca: Wolters Kluwer Health
    Status:
    Published
    DOI:
    10.1097/HJH.0000000000002864 - link to the publication
  3. TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts haemodynamic effects: implications for interpretation of cardiovascular actions of gut microbiome
    Authors:
    Kinga Jaworska, Klaudia Bielinska, Marta Gawrys-Kopczynska, Marcin Ufnal
    Academic press:
    Cardiovasc Research (rok: 2019, tom: 115, strony: 1948–1949), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/cvr/cvz231 - link to the publication
  4. Hypertensive rats show increased renal excretion and decreased tissue concentrations of glycine betaine, a protective osmolyte with diuretic properties.
    Authors:
    Izabella Mogilnicka; Mateusz Koper; Klaudia Maksymiuk; Mateusz Szudzik; Mariusz Radkiewicz; Dawid Chabowski; Marcin Ufnal
    Academic press:
    Physiological Reports (), Wydawca: Plos one
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology
    Authors:
    Kinga Jaworska, Dagmara Hering, Grażyna Mosieniak, Anna Bielak-Zmijewska, Marta Pilz, Michał Konwerski, Aleksandra Gasecka, Agnieszka Kapłon-Cieślicka, Krzysztof Filipiak, Ewa Sikora, Robert Hołyst, Marcin Ufnal
    Academic press:
    Toxins (rok: 2019, tom: 11, strony: 490), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/toxins11090490 - link to the publication
  6. Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite
    Authors:
    Adrian Drapala, Mateusz Szudzik , Dawid Chabowski, Izabella Mogilnicka, Kinga Jaworska, Katarzyna Kraszewska, Emilia Samborowska, Marcin Ufnal
    Academic press:
    Int J Mol Sci (rok: 2020, tom: 21, strony: 6161), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176161. - link to the publication
  7. Mice, Rats and Guinea Pigs Exhibit Significant Variations in the Plasma, Urine and Tissue Levels of Taurine, Betaine, Sarcosine and Other Osmolyte-Active Amino Acids
    Authors:
    Lenka Tomasova, Klaudia Maksymiuk, Dawid Chabowski, Emilia Samborowska, Marcin Ufnal
    Academic press:
    Discovery Medicine (rok: 2023, tom: 35, strony: 492-502), Wydawca: Discovery Medicine
    Status:
    Accepted for publication
    DOI:
    10.24976/Discov.Med.202335177.50 - link to the publication

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