Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Involvement of RIPk4 in melanoma malignacy regulated by Wnt/b-catenin signaling.

2018/31/B/NZ5/01423

Keywords:

RIPK4 b-catenin melanoma malignacy apoptosis

Descriptors:

  • NZ1_2: Biochemistry
  • NZ3_7: Signal transduction
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Wolnicka-Głubisz 

Number of co-investigators in the project: 10

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 456 500 PLN

Project start date (Y-m-d): 2019-07-05

Project end date (Y-m-d): 2024-07-04

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Vemurafenib and Dabrafenib Downregulates RIPK4 Level
    Authors:
    Madej E, Brożyna AA, Adamczyk A, Wronski N, Harazin-Lechowska A, Muzyk A, Makuch K, Markiewicz M, Rys J, Wolnicka-Glubisz A.
    Academic press:
    Cancers (rok: 2023, tom: 15, strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15030918. - link to the publication
  2. Deciphering the functional role of RIPK4 in melanoma.
    Authors:
    Madej Ewelina, Ryszawy Damian, Brozyna Anna, Czyz Małgorzata, Czyz Jarosław, Wolnicka-Głubisz Agnieszka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11504), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111504 - link to the publication
  3. Rola białka RIPK4 w fizjologii naskórka.
    Authors:
    Madej Ewelina, Lisek Anna, Wolnicka-Głubisz Agnieszka
    Academic press:
    Postępy Biochemii (rok: 2021, tom: 67, strony: 64-71), Wydawca: Uniwersytet Warszawski
    Status:
    Published
    DOI:
    10.18388/pb.2021_370 - link to the publication
  4. RIPK4 downregulation impairs Wnt3A-stimulated invasiveness via Wnt/b-catenin signaling in melanoma cells and tumor growth in vivo
    Authors:
    Wroński Norbert, Madej Ewelina, Grabacka Maja, Brożyna Anna A., Wolnicka-Głubisz Agnieszka
    Academic press:
    Cellular Signalling (rok: 2024, tom: 113, strony: 12), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2023.110938 - link to the publication
  5. RIPK4 via p38 and BIRC3/p65 regulates TNF-α- stimulated IL-6 and IL-8 production by melanoma cells
    Authors:
    Ewelina Madej, Anna Lisek, Anna A. Brożyna, Agnieszka Cierniak, Norbert Wronski, Milena Deptula, Anna Wardowska, Agnieszka Wolnicka-Glubisz
    Academic press:
    Journal of Cancer Research and Clinical Oncology (rok: 2024, tom: brak, strony: 13), Wydawca: Springer
    Status:
    Submitted
    DOI:
    brak - link to the publication

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