Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Nanoparticle Transfer Through Endothelial Barrier

2018/30/Z/NZ1/00911

Keywords:

biological barrier nanoparticles neurosciences biological sciences blood brain barrier

Descriptors:

  • :

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bryszewska 

Number of co-investigators in the project: 1

Call: UNISONO

Amount awarded: 636 440 PLN

Project start date (Y-m-d): 2019-10-01

Project end date (Y-m-d): 2024-08-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (1)
  1. Heterofunctional ruthenium(II) carbosilane dendrons, a new class of dendritic molecules to fight against prostate cancer
    Authors:
    Natalia Sanz del Olmo, Marta Maroto-Diaz, Sara Quintana, Rafael Gomez, Marcin Holota, Maksim Ionov, Maria Bryszewska, M. Jose Carmena, Paula Ortega, F. Javier de la Mata
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2020, tom: 207, strony: 112695, s. 1-11), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.112695 - link to the publication
  2. Pegylated Gold Nanoparticles Conjugated with siRNA: Complexes Formation and Cytotoxicity.
    Authors:
    E. Okła, P. Białecki, M. Kiędzierska, E. Pedziwiatr-Werbicka, K. Milowska, S. Takvor, R. Gómez Ramírez, F. J. De la Mata, M. Bryszewska, M. Ionov.
    Academic press:
    Int. J. Mol. Sci (rok: 2023, tom: 24, strony: 6638), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24076638 - link to the publication
  3. Synthesis and biophysical evaluation of carbosilane dendrimers as therapeutic siRNA carriers
    Authors:
    S. Zawadzki, Á. Martín-Serrano, E. Okła, M. Kędzierska, S. Garcia-Gallego, P. O. López, F. J. de la Mata, S. Michlewska, T. Makowski, M. Ionov, E. Pędziwiatr-Werbicka, M. Bryszewska, K. Miłowska
    Academic press:
    Sci. Rep. (rok: 2024, tom: 14, strony: 1615), Wydawca: NATURE PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.1038/s41598-024-51238-w - link to the publication
  4. The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes
    Authors:
    Dorota Kuc-Ciepluch, Michał Gorzkiewicz, Elżbieta Pędziwiatr-Werbicka, Andrea Barrios-Gumiel, Magdalena Lasak, Aleksandra Mariak, Krzysztof Sztandera, Rafael Gomez, F. Javier de la Mata, Anna Lankoff, Barbara Klajnert-Maculewicz, Maria Bryszewska, Michał Arabski, Karol Ciepluch
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2022, tom: 217, strony: 112652, s. 1-9), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2022.112652 - link to the publication
  5. The effect of maltose modified fourth generation poly(propylene imine) (PPI G4) dendrimers on the barrier functions and inflammatory activation of human vascular endothelium – Possible consequences for the medical application
    Authors:
    Maciej Chałubinski, Aleksandra Szulc, Paulina Gorzelak-Pabis , Katarzyna Wojdan, Dietmar Appelhans, Maria Bryszewska, Marlena Broncel
    Academic press:
    Vascular Pharmacology (rok: 2022, tom: 143, strony: 106972), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Copper (II) metallodendrimers combined with pro- apaoptotic siRNAs as a promising strategy against breast cancer cells
    Authors:
    Natalia Sanz del Olmo, Marcin Hołota, Sylwia Michlewska, Rafael Gomez, Paula Ortega, Maksim Ionov, Francisco Javier de la Mata, Maria Bryszewska
    Academic press:
    Pharmaceutics (rok: 2020, tom: 12, 727, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12080727 - link to the publication
  7. Cyclopentadienyl ruthenium(II) carbosilane metallodendrimers as a promising treatment against advanced prostate cancer, Rafael Gómez, Paula Ortega, F. Javier de la Mata
    Authors:
    Natalia Sanz del Olmo, Ana Bajo, Maksim Ionov, Sandra Garcia-Gallego, Maria Bryszewska, Rafael Gómez, Paula Ortega, F. Javier de la Mata
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2020, tom: 199, 112414, strony: 12420), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.112414 - link to the publication
  8. PEGylation of Dendronized Gold Nanoparticles Affects Their Interaction with Thrombin and siRNA
    Authors:
    Elżbieta Pędziwiatr-Werbicka, Michał Gorzkiewicz, Katarzyna Horodecka, Dominika Lach, Andrea Barrios-Gumiel, Javier Sanchez-Nieves, Rafael Gomez, Francisco Javier de la Mata, and Maria Bryszewska,
    Academic press:
    The Journal of Physical Chemistry B (rok: 2021, tom: 125, strony: 1196-1206), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c10177 - link to the publication
  9. Ruthenium dendrimers against human lymphoblastic leukemia 1301 cells,
    Authors:
    Sylwia Michlewska, Maksim Ionov, Aleksandra Szwed, Aneta Rogalska, Natalia Sanz del Olmo, Paula Ortega, Marta Denel, Damian Jacenik, Dzmitry Shcharbin, Francisco Javier de la Mata, Maria Bryszewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 214119, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21114119 - link to the publication
  1. Oddziaływanie dendrymerów zawierających atomy miedzi z aminotransferazą asparaginianową (AST)
    Authors:
    Marika Grodzicka, Małgorzata Kubczak, Sylwia Michlewska, Maksim Ionov, Maria Bryszewska.
    Conference:
    XIII Interdyscyplinarna Konferencja naukowa TYGIEL 2021 "Interdyscyplinarność kluczem do rozwoju" (rok: 2021, ), Wydawca: Wydawnictwo Naukowe TYGIEL sp. z o.o.
    Data:
    konferencja 25-28 marca 2021
    Status:
    Published

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