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Nutrition, epigenetics and disease - Effects of a ketogenic diet and beta-hydroxybutyrate on crucial epigenetic signatures of the histone code. Analysis of their potential benficial value in metabolic disorders.

2018/30/M/NZ3/00682

Keywords:

beta-hydroxybutyrate endothelial cells ketogenic diet epigenetic modifications of histones

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_2: Biochemistry
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Aneta Balcerczyk 

Number of co-investigators in the project: 9

Call: HARMONIA 10 - announced on 2018-06-15

Amount awarded: 946 400 PLN

Project start date (Y-m-d): 2019-05-13

Project end date (Y-m-d): 2024-11-12

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and pathological states.
    Authors:
    Dąbek A, Wojtala M, Pirola L, Balcerczyk A.
    Academic press:
    Nutrients (rok: 2020, tom: 12 (7), strony: 788-802), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12030788 - link to the publication
  2. Fat not so bad? The role of ketone bodies and ketogenic diet in the treatment of endothelial dysfunction and hypertension
    Authors:
    Luciano Pirola, Oskar Ciesielski, Aneta Balcerczyk
    Academic press:
    Biochemical Pharmacology (rok: 2022, tom: 206, strony: 115345-115354), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2022.115346 - link to the publication
  3. The effects of ketogenic diet and ketone bodies on the cardiovascular system. Concentration matters
    Authors:
    Nasser S, Vialichka B, Biesiekierska M, Balcerczyk A, Pirola L.
    Academic press:
    World Journal of Diabetes (rok: 2020, tom: 11(12), strony: 584-595), Wydawca: Baishideng Publishing Group
    Status:
    Published
    DOI:
    10.4239/wjd.v11.i12.584 - link to the publication
  4. Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney
    Authors:
    Souad Nasser, Thomas Solé, Nathalie Vega, Thierry Thomas, Aneta Balcerczyk, Maura Strigini, Luciano Pirola
    Academic press:
    Molecular Metabolism (rok: 2022, tom: 79, strony: 94-107), Wydawca: Science Direct
    Status:
    Published
    DOI:
    10.1016/j.molmet.2022.101578 - link to the publication

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