Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Dissecting DNA Maintenance Methylation in Mammals: Fidelity, Timing and Instructive Cues

2018/30/Q/NZ2/00669

Keywords:

DNA methylation maintenance fidelity timing nascent strand chromatin DNMT TET

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_1: Molecular genetics
  • NZ1_1: Molecular biology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Matthias Bochtler 

Number of co-investigators in the project: 4

Call: SHENG 1 - announced on 2018-06-15

Amount awarded: 1 737 600 PLN

Project start date (Y-m-d): 2019-10-02

Project end date (Y-m-d): 2024-10-01

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Reversal of nucleobase methylation by dioxygenases
    Authors:
    Xu GL & Bochtler M
    Academic press:
    Nature Chemical Biology (rok: 2020, tom: 16, strony: 1160–1169), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41589-020-006 - link to the publication
  2. DNA adenine methylation in eukaryotes: Enzymatic mark or a form of DNA damage?
    Authors:
    Bochtler M & Fernandes H
    Academic press:
    BioEssays (rok: 2021, tom: 43, strony: e2000243), Wydawca: Wiley Periodicals LLC
    Status:
    Published
    DOI:
    10.1002/bies.202000243 - link to the publication
  3. Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.
    Authors:
    Ravichandran M, Rafalski D, Davies CI, Ortega-Recalde O, Nan X, Glanfield CR, Kotter A, Misztal K, Wang AH, Wojciechowski M, Rażew M, Mayyas IM, Kardailsky O, Schwartz U, Zembrzycki K, Morison IM, Helm M, Weichenhan D, Jurkowska RZ, Krueger F, Plass C, Zacharias M, Bochtler M, Hore TA, Jurkowski TP.
    Academic press:
    Science Advances (rok: 2022, tom: 8, strony: 45306), Wydawca: Science
    Status:
    Published
    DOI:
    10.1126/sciadv.abm2427 - link to the publication

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