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Information on the principal investigator and host institution

Information of the project and the call

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Role of RNA binding proteins in resistance to therapy of leukemia cells in bone marrow niche

2018/30/M/NZ3/00274

Keywords:

leukemia mikroenvironment RBPs synthetic lethality DNA damage translacja

Descriptors:

  • NZ3_3: Apoptosis
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Podszywałow-Bartnicka 

Number of co-investigators in the project: 6

Call: HARMONIA 10 - announced on 2018-06-15

Amount awarded: 1 500 000 PLN

Project start date (Y-m-d): 2019-05-16

Project end date (Y-m-d): 2024-05-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (5)
  • Book publications / chapters in book publications (1)
  1. TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
    Authors:
    Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P.
    Academic press:
    iScience (rok: 2023, tom: 26(4), strony: 106543), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/ - link to the publication
  2. TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
    Authors:
    Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T.
    Academic press:
    Cell Reports (rok: 2020, tom: 33 (1), strony: 108221-), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2020.108221. - link to the publication
  3. Splicing under stress: A matter of time and place
    Authors:
    Paulina Podszywalow-Bartnicka and Karla M. Neugebauer
    Academic press:
    Journal of Cell Biology (rok: 2023, tom: 222, strony: e202311014), Wydawca: Rockefeller University Press
    Status:
    Published
    DOI:
    10.1083/jcb.202311014 - link to the publication
  4. Pre-Existing and Acquired Resistance to PARP Inhibitor-Induced Synthetic Lethality
    Authors:
    Bac Viet Le, Paulina Podszywałow-Bartnicka, Katarzyna Piwocka, Tomasz Skorski
    Academic press:
    Cancers (rok: 2022, tom: 14(23), strony: 5795), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14235795 - link to the publication
  1. 'Nascent proteome of leukemia cells in the hypoxic bone marrow microenvironment – role of TIAR and FMRP'
    Authors:
    Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P.
    Conference:
    American Society of Biochemistry and Molecular Biology Annual Meeting (rok: 2023, ), Wydawca: Journal of Biological Chemistry
    Data:
    konferencja 25-28.03.2023
    Status:
    Published
  2. Influence of hypoxia on the RNA binding proteins complexes and translation in leukemia cells
    Authors:
    Wolczyk M, Jakubik M, Turos LA, Wiech M, Dabrowska Z, Piwocka K, Podszywalow-Bartnicka P.
    Conference:
    RNA Society Meeting (rok: 2020, ), Wydawca: RNA Society
    Data:
    konferencja 26-31.05.2020
    Status:
    Published
  3. Role of mRNA regulation by TIAR in leukemia cell resistance to therapy in the hypoxic bone marrow microenvironment
    Authors:
    Wolczyk M, Serwa R, Dabrowski M, Schaerfen L, Piwocka K, Neugebauer K, Podszywalow-Bartnicka P
    Conference:
    Cold Spring Harbor Laboratory Conference on 'Eukaryotic mRNA Processing' (rok: 2023, ), Wydawca: Cold Spring Harbor Laboratory, NY, USA
    Data:
    konferencja 22-26.08.2023
    Status:
    Published
  4. Impact of chronic myeloid leukemia environment on the level of DNA-double stand break and activation of repair pathways
    Authors:
    Jakubik M, Kominek A, Piwocka K, Podszywałow-Bartnicka P.
    Conference:
    9. Międzyuczelniane Sympozjum Biotechnologiczne "Symbioza" (rok: 2021, ), Wydawca: Warszawskie Stowarzyszenie Biotechnologiczne Symbioza"
    Data:
    konferencja 21-23.05.2021
    Status:
    Published
  5. Abstract P09: Splicing and translation in chronic myeloid leukemia cells adapting to bone marrow microenvironment and chemotherapy
    Authors:
    Ewa Kozlowska; Remigiusz Serwa; Morgan Shine; Magda Wolczyk; Paulina Pilanc-Kudlek; Agata Kominek; Bac Viet Le; Ewa Walejewska; Joanna Idaszek; Wojciech Swieszkowski; Katarzyna Piwocka; Tomasz Skorski; Karla M Neugebauer; Paulina Podszywalow-Bartnicka
    Conference:
    American Association for Cancer research 'Blood Cancer Discovery' (rok: 2024, ), Wydawca: AACR
    Data:
    konferencja 04-06.03.2024
    Status:
    Published
    DOI:
    link to the publication
  1. Targeting of Post-Transcriptional Regulation as Treatment Strategy in Acute Leukemia
    Authors:
    Podszywalow-Bartnicka P, Wolczyk M, Piwocka K
    Book:
    Acute Leukemias (rok: 2020, tom: xxx, strony: xxx), Wydawca: Intech Open
    Status:
    Published

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