Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Hydrogels composed of dynamic cross-links of controlled diffusivity and enhanced solubility of drugs for gynecological treatment

2018/30/E/ST5/00576

Keywords:

hydrogel reversible cross-links hydrophobic drugs network diffusivity gynecology

Descriptors:

  • ST5_1:
  • ST5_21:
  • ST5_22:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Monika Gosecka 

Number of co-investigators in the project: 6

Call: SONATA BIS 8 - announced on 2018-06-15

Amount awarded: 2 067 500 PLN

Project start date (Y-m-d): 2019-09-02

Project end date (Y-m-d): 2024-12-01

Project duration:: 63 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  • Book publications / chapters in book publications (1)
  1. Composite Dynamic Hydrogels Constructed on Boronic Ester Cross-Links with NIR-Enhanced Diffusivity
    Authors:
    Monika Gosecka*, Mateusz Gosecki, Malgorzata Urbaniak
    Academic press:
    Biomacromolecules (rok: 2022, tom: 23, strony: 948–959), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biomac.1c01359 - link to the publication
  2. Chemoresponsive polymer systems for selective molecular recognition of organic molecules in biological systems
    Authors:
    Monika Gosecka*, Mateusz Gosecki
    Academic press:
    Acta Biomaterialia (rok: 2020, tom: 116, strony: 32-66), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.actbio.2020.08.039 - link to the publication
  3. Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications
    Authors:
    Yin, BH. ; Gosecka, M.; Bodaghi, M.; Youssef, G. ; Dodda, JM. Wong, SHD; Bin Imran, A. ; Gosecki, M.; Jobdeedamrong, A
    Academic press:
    Chemical Engineering Journal (rok: 2024, tom: 487, strony: 150403), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cej.2024.150403 - link to the publication
  4. Thermosensitive Behavior of Internally Phenyl-Enriched Hyperbranched Polyglycidols in Water-The Influence of a Covalent Bond Used for the Hydrophobization
    Authors:
    Jaworska-Krych, D (Jaworska-Krych, Daria) [1] ; Gosecka, M.; Maczugowska, P; Halagan, K.; Szutkowski, K. ; Gosecki, M; Urbaniak, M.; Kozanecki, M
    Academic press:
    Macromolecules (rok: 2024, tom: 57, strony: 9135-9156), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.macromol.4c01709 - link to the publication
  5. Evaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation
    Authors:
    Mateusz Gosecki, Malgorzata Urbaniak, Nuno Martinho, Monika Gosecka,* and Mire Zloh
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 7308), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/molecules28217308 - link to the publication
  6. Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies
    Authors:
    Piotr Ziemczonek, Monika Gosecka, Mateusz Gosecki, Monika Marcinkowska, Anna Janaszewska, Barbara Klajnert-Maculewicz
    Academic press:
    International Journal of molecular Sciences (rok: 2021, tom: 22, strony: 8386), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/ijms22168386 - link to the publication
  7. Cross-linkable star-hyperbranched unimolecular micelles for the enhancement of the anticancer activity of clotrimazole
    Authors:
    Mateusz Gosecki, Piotr Ziemczonek, Monika Gosecka, Malgorzata Urbaniak, Ewelina Wielgus, Monika Marcinkowska, Anna Janaszewska, Barbara Klajnert-Maculewicz
    Academic press:
    Journal of Materials Chemistry B (rok: 2023, tom: 11, strony: 5552-5564), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2tb02629e - link to the publication
  8. Introduction to Polymer Upcycling
    Authors:
    Blair Brettmann, Marco A. Fraga, Monika Gosecka, Natalie Stingelin
    Academic press:
    Journal of Materials Chemistry A (rok: 2023, tom: 11, strony: 5975-5977), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d3ta90040a - link to the publication
  9. Selective Anticervical Cancer Injectable and Self-Healable Hydrogel Platforms Constructed of Drug-Loaded Cross-Linkable Unimolecular Micelles in a Single and Combination Therapy
    Authors:
    Monika Gosecka*, Mateusz Gosecki, Piotr Ziemczonek, Malgorzata Urbaniak, Ewelina Wielgus, Monika Marcinkowska, Anna Janaszewska*, and Barbara Klajnert-Maculewicz
    Academic press:
    ACS Applied Materials and Interfaces (rok: 2024, tom: 16, strony: 14605-14625), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsami.4c01524 - link to the publication
  10. Antimicrobial Polymer-Based Hydrogels for the Intravaginal Therapies—Engineering Considerations
    Authors:
    Monika Gosecka*, Mateusz Gosecki
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 1393), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13091393 - link to the publication
  11. Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology
    Authors:
    Monika Gosecka, Daria Jaworska-Krych, Mateusz Gosecki, Ewelina Wielgus, Monika Marcinkowska, Janaszewska, Barbara Klajnert-Maculewicz
    Academic press:
    Biomacromolecules (rok: 2022, tom: 23, strony: 4203-4219), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.biomac.2c00691 - link to the publication
  12. Hydrophobized hydrogels: construction strategies, properties, and biomedical applications
    Authors:
    Monika Gosecka*, Mateusz Gosecki, Daria Jaworska-Krych
    Academic press:
    Advanced Functional Materials (rok: 2023, tom: 33, strony: 2212302), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/adfm.202212302 - link to the publication
  13. The influence of 2-acrylamidephenylboronic acid on the phase behaviour of its copolymers with N-isopropylacrylamide in aqueous solution
    Authors:
    Mateusz Gosecki, Piotr Ziemczonek, Paulina Maczugowska, Anna Czaderna-Lekka, Marcin Kozanecki, Monika Gosecka*
    Academic press:
    Polymer Chemistry (rok: 2021, tom: 12, strony: 3264–3275), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1py00397f - link to the publication
  14. Enhanced Solubility and Bioavailability of Clotrimazole in Aqueous Solutions with Hydrophobized Hyperbranched Polyglycidol for Improved Antifungal Activity
    Authors:
    Jaworska-Krych, D.; Gosecka, M; Gosecki, M.; Urbaniak, M ; Dzitko, K.; Ciesielska, A. ; Wielgus, E.; Kadlubowski, S.; Kozanecki, M
    Academic press:
    ACS APPLied Materials and Interfaces (rok: 2024, tom: 16, strony: 18434-18448), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsami.3c19388 - link to the publication
  1. Nieliniowe polietery jako główny składnik dynamicznych hydrożeli będących nośnikami leków hydrofobowych
    Authors:
    Monika Gosecka, Piotr ZZiemczonek, Daria Jaworska-Krych, Mateusz Gosecki, Małgorzata Urbaniak, Monika Marcinkowska, Anna Janaszewska, Barbara Klajnert-Maculewicz
    Book:
    Modyfikacja Polimerów. Stan i Perspektywy w roku 2023 (rok: 2023, tom: 1, strony: 66-70), Wydawca: Politechnika Wrocławska
    Status:
    Published

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