Projects funded by the NCN
Development and study of photodynamic and Ga loaded high efficient and dual-functional antimicrobial agents
2018/30/Q/NZ7/00281
Keywords:
antimicrobial dual functional ESKAPE Fe-blocking photodynamic therapy
Descriptors:
- NZ7_14:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego
woj. pomorskie
Principal investigator (from the host institution):
dr hab. Mariusz Stanisław Grinholc
Number of co-investigators in the project: 7
Call: SHENG 1 - announced on 2018-06-15
Amount awarded: 1 752 800 PLN
Project start date (Y-m-d): 2019-10-02
Project end date (Y-m-d): 2023-10-01
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (5)
- Gallium Mesoporphyrin IX-Mediated Photodestruction: A Pharmacological Trojan Horse Strategy To Eliminate Multidrug- Resistant Staphylococcus aureusAuthors:Klaudia Michalska, Michał Rychłowski, Martyna Krupińska, Grzegorz Szewczyk, Tadeusz Sarna, Joanna NakoniecznaAcademic press:ACS Molecular Pharmaceutics (rok: 2022, tom: 19, strony: 1434-1448), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.molpharmaceut.1c00993 - link to the publication
- Iron-blocking antibacterial therapy with cationic heme-mimetic gallium porphyrin photosensitizer for combating antibiotic resistance and enhancing photodynamic antibacterial activityAuthors:Hao Zhang, Qingsi Li, Xiaoyu Qi, Yi Li, Hongyan Ma, Mariusz Grinholc, Joanna Nakonieczna, Bingran Yu, Xing Wang, Lei ZhangAcademic press:Chemical Engineering Journal (rok: 2023, tom: 451, strony: 138261), Wydawca: Elsevier Science SAStatus:PublishedDOI:10.1016/j.cej.2022.138261 - link to the publication
- Development of Antimicrobial Phototreatment Tolerance: Why the Methodology MattersAuthors:Aleksandra Rapacka-Zdończyk, Agata Woźniak, Joanna Nakonieczna, Mariusz GrinholcAcademic press:International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 2224), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms22042224 - link to the publication
- Decrease of ESKAPE virulence with a cationic heme-mimetic gallium porphyrin photosensitizer: The Trojan horse strategy that could help address antimicrobial resistanceAuthors:Klaudia Szymczak, Agata Woźniak-Pawlikowska, Natalia Burzyńska, Magdalena Król, Lei Zhang, Joanna Nakonieczna, Mariusz GrinholcAcademic press:Journal of Photochemistry and Photobiology B-Biology (rok: 2024, tom: 256, strony: 112928), Wydawca: Elsevier Science SAStatus:PublishedDOI:10.1016/j.jphotobiol.2024.112928 - link to the publication
- Photoactivated Gallium Porphyrin Reduces Staphylococcus aureus Colonization on the Skin and Suppresses Its Ability to Produce Enterotoxin C and TSST-1Authors:Klaudia Szymczak, Grzegorz Szewczyk, Michał Rychłowski, Tadeusz Sarna, Lei Zhang, Mariusz Grinholc, Joanna NakoniecznaAcademic press:ACS Molecular Pharmaceutics (rok: 2023, tom: 20, strony: 5108-5124), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.molpharmaceut.3c00399 - link to the publication