Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Fusion peptides and transmembrane domains of selected enveloped viruses: structure, dynamics and interactions with membrane

2018/30/E/NZ1/00257

Keywords:

membrane fusion virus-like particle peptide-lipid interaction

Descriptors:

  • NZ1_3:
  • NZ1_6:
  • ST4_13:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Fizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Remigiusz Worch 

Number of co-investigators in the project: 7

Call: SONATA BIS 8 - announced on 2018-06-15

Amount awarded: 2 997 000 PLN

Project start date (Y-m-d): 2019-04-17

Project end date (Y-m-d): 2025-01-16

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Transient Excursions to Membrane Core as Determinants of Influenza Virus Fusion Peptide Activity
    Authors:
    Remigiusz Worch, Anita Dudek, Paulina Borkowska, Piotr Setny
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 46042), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22105301 - link to the publication
  2. Influenza A H1 and H3 Transmembrane Domains Interact Differently with Each Other and with Surrounding Membrane Lipids
    Authors:
    Szymon Kubiszewski-Jakubiak; Remigiusz Worch
    Academic press:
    Viruses (rok: 2020, tom: 1461, strony: 46035), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v12121461 - link to the publication
  3. Integrating Cryo-Electron Microscopy and Molecular Dynamics Simulations to Investigate Membrane Binding of Influenza Virus Fusion Peptide
    Authors:
    Piotr Setny, Paulina Borkowska, Remigiusz Worch
    Academic press:
    Journal of the American Chemical Society (rok: 2025, tom: 147, strony: 13385-13395), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.4c18441 - link to the publication
  4. Unique properties of Coronaviridae single-pass transmembrane domain regions as an adaptation to diverse membrane systems
    Authors:
    Szymon Kubiszewski-Jakubiak, Remigiusz Worch
    Academic press:
    Virology (rok: 2022, tom: 570, strony: 46030), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.virol.2022.03.002 - link to the publication