Projects funded by the NCN
Biochemical bases of ectopic calcification of skeletal muscles in animal model of Duchenne muscular dystrophy (mdx mice)
2018/29/B/NZ4/02440
Keywords:
muscular dystrophy muscle calcification ER-stress nucleotide receptor P2RX7
Descriptors:
- NZ4_5: Anatomical pathology
- NZ4_2: Physiology
- NZ4_11: Metabolism
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: OPUS 15 - announced on 2018-03-15
Amount awarded: 1 446 200 PLN
Project start date (Y-m-d): 2019-01-15
Project end date (Y-m-d): 2023-01-14
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic MusclesAuthors:Rumney RMH, Róg J, Chira N, Kao AP, Al-Khalidi R, Górecki DC.Academic press:Frontiers in Pharmacology (rok: 2022, tom: 13, strony: 0), Wydawca: FrontiersStatus:PublishedDOI:10.3389/fphar.2022.935804 - link to the publication
- Total Absence of Dystrophin Expression Exacerbates Ectopic Myofiber Calcification and Fibrosis and Alters Macrophage Infiltration Patterns.Authors:Young CNJ, Gosselin MRF, Rumney R, Oksiejuk A, Chira N, Bożycki Ł, Matryba P, Łukasiewicz K, Kao AP, Dunlop J, Robson SC, Zabłocki K, Górecki DC.Academic press:Americam Journal of Pathology (rok: 2020, tom: 190, strony: 190-205), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ajpath.2019.09.021 - link to the publication