Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of klotho and NPP1 proteins in regulation of podocyte function.

2018/29/B/NZ4/02074

Keywords:

podocyte klotho phosphate and calcium homeostasis metalloproteinases glomerular filtration barrier diabetic nephropathy insulin resistance

Descriptors:

  • NZ3_2: Cell physiology
  • NZ5_3: Pathogenesis of human diseases
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Piwkowska 

Number of co-investigators in the project: 9

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 2 320 560 PLN

Project start date (Y-m-d): 2019-01-31

Project end date (Y-m-d): 2022-06-29

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikroskop konfokalno-superrozdzielczy (496 100 PLN)
  2. Luminometr (53 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (3)
  1. The impact of type III sodium-dependent phosphate transporters (Pit 1 and Pit 2) on podocyte and kidney function.
    Authors:
    Kulesza Tomasz, Piwkowska Agnieszka
    Academic press:
    Journal of Cellular Physiology (rok: 2021, tom: 236, strony: 7176-7185), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.30368 - link to the publication
  2. Hyperglycemic environment disrupts phosphate transporter function and promotes calcification processes in podocytes and isolated glomeruli.
    Authors:
    Tomasz Kulesza, Marlena Typiak, Patrycja Rachubik, Irena Audzeyenka, Dorota Rogacka, Stefan Angielski, Moin A Saleem, Agnieszka Piwkowska
    Academic press:
    Journal of Cellular Physiology (rok: 2022, tom: brak, strony: brak), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.30700 - link to the publication
  3. Role of Klotho in hyperglycemia: its levels and effects on fibroblast growth factor receptors, glycolysis, and glomerular filtration.
    Authors:
    M. Typiak, T. Kulesza, P. Rachubik, D. Rogacka, I. Audzeyenka, S. Angielski, M. Saleem, A. Piwkowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 7867-7878), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22157867 - link to the publication
  4. Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy.
    Authors:
    Typiak Marlena, Piwkowska Agnieszka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 956), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020956 - link to the publication
  1. αKlotho as a major regulator of podocyte function in hyperglycemia
    Authors:
    Agnieszka Piwkowska, Marlena Typiak, Irena Audzeyenka, Patrycja Rachubik, Tomasz Kulesza, Stefan Angielski, Dorota Rogacka
    Conference:
    XIV Zjazd Polskiego Towarzystwa Nefrologicznego (rok: 2022, ), Wydawca: Uniwersytet Medyczny we Wrocławiu
    Data:
    konferencja 9-11 czerwiec
    Status:
    Published
  2. Characteristics of ADAM10 by combinatorial chemistry methods
    Authors:
    N. Gruba, J. Pianka, A. Piwkowska, A. Lesner
    Conference:
    25th Polish Peptide Symposium (rok: 2019, ), Wydawca: Wrocław Medical University
    Data:
    konferencja 8-12 wrzesień
    Status:
    Published
  3. Synthesis of specific substrate for ADAM17 using combinatorial chemistry methods
    Authors:
    Honorata Sikora, Natalia Gruba, Agnieszka Piwkowska, Adam Lesner, Magdalena Wysocka
    Conference:
    Cystatins 2022 (rok: 2022, ), Wydawca: Uniwersytet Gdański Wydział Chemii
    Data:
    konferencja 16-18 czerwciec
    Status:
    Published

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