Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular analysis of the structural disorder of the Nucleobindin-2, a protein with multiple functions

2018/29/B/NZ1/02574

Keywords:

nucleobindin nesfatin intrinsically disordered proteins intrinsically disordered regions circular dichroism AUC SAXS HDX calcium ions binding

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_3: Biophysics
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Ożyhar 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 258 000 PLN

Project start date (Y-m-d): 2019-05-06

Project end date (Y-m-d): 2023-05-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Urządzenie do Real-time PCR (250 000 PLN)
  2. Wytwornica lodu.
  3. Licznik komórek TC20 Auto Cell Counter & Cell Count.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Calcium ions modulate the structure of the intrinsically disordered Nucleobindin-2 protein
    Authors:
    Anna Skorupska, Dominika Bystranowska, Katarzyna Dąbrowska, Andrzej Ożyhar
    Academic press:
    International Journal of Biological Macromolecules (rok: 2020, tom: 154, strony: 1091-1104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2020.03.110 - link to the publication
  2. Nesfatin-3 possesses divalent metal ion binding properties, which remain hidden in the nucleobindin-2 precursor protein
    Authors:
    Anna Skorupska-Stasiak, Dominika Bystranowska, Józef Ba Tran, Artur Krężel, Andrzej Ożyhar
    Academic press:
    Cell Communications and Signaling , Wydawca: Springer Nature
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  3. The multifaceted nature of Nucleobindin-2 in carcinogenesis
    Authors:
    Anna Skorupska, Rafał Lenda, Andrzej Ożyhar, Dominika Bystranowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 225687, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22115687 - link to the publication
  4. Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2
    Authors:
    Rafał Lenda, Michał Padjasek, Artur Krężel, Andrzej Ożyhar, Dominika Bystranowska
    Academic press:
    Cell Communication and Signaling (rok: 2022, tom: 20, strony: 45310), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-022-00980-7 - link to the publication
  5. Nucleobindin-2 consists of two structural components: The Zn2+-sensitive N-terminal half, consisting of nesfatin-1 and -2, and the Ca2+-sensitive C-terminal half, consisting of nesfatin-3
    Authors:
    Bystranowska D, Skorupska A, Sołtys K, Padjasek M, Krężel A, Żak A, Kaus-Drobek M, Taube M, Kozak M, Ożyhar A.
    Academic press:
    Comput Struct Biotechnol J. (rok: 2021, tom: 19, strony: 4300-4318), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2021.07.036 - link to the publication
  1. Conformational changes of nesfatin-1 in the presence of Zn(II) ions
    Authors:
    R. Lenda, A. Ozyhar, D. Bystranowska
    Conference:
    The 45th FEBS Congress (rok: 2021, ), Wydawca: FEBS Open Bio © 2021 FEBS Wiley
    Data:
    konferencja 2021-07-03 - 2021-07-08
    Status:
    Published
    DOI:
    link to the publication
  2. The Zn2+ -dependent change of Nucleobindin-2 structure
    Authors:
    A. Skorupska, M. Kaus -Drobek, A. Ozyhar, D. Bystranowska
    Conference:
    The 45th FEBS Congress (rok: 2021, ), Wydawca: FEBS Open Bio © 2021 FEBS Wiley
    Data:
    konferencja 2021-07-03 - 2021-07-08
    Status:
    Published
    DOI:
    link to the publication

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