Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Non-vitamin K antagonist oral anticoagulants (NOACs) as modulators of valvular calcification and inflammation in aortic stenosis in humans

2018/29/B/NZ5/02629

Keywords:

aortic stenosis coagulation inflammations metalloproteinases NOACs NF-kB factor

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Krakowski Szpital Specjalistyczny im. św. Jana Pawła II

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Natorska 

Number of co-investigators in the project: 4

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 123 600 PLN

Project start date (Y-m-d): 2019-02-06

Project end date (Y-m-d): 2024-08-05

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Neutrophil extracellular traps (NETs) in aortic stenosis: Comparison of methods for assessment of NETs formation
    Authors:
    Piotr Kopiński, Magdalena Kopytek, Michał Ząbczyk, Anetta Undas, Joanna Natorska
    Academic press:
    Advances in Hygiene and Experimental Medicine (rok: 2023, tom: 77, strony: 163-169), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/ahem-2023-0018 - link to the publication
  2. PAI-1 Overexpression in Valvular Interstitial Cells Contributes to Hypofibrinolysis in Aortic Stenosis.
    Authors:
    Kopytek M, Ząbczyk M, Mazur P, Undas A, Natorska J.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 1402), Wydawca: MDPI Journals
    Status:
    Published
    DOI:
    10.3390/cells12101402. - link to the publication
  3. Diabetes mellitus as a risk factor for aortic stenosis: from new mechanisms to clinical implications
    Authors:
    Natorska J
    Academic press:
    Kardiologia Polska (rok: 2021, tom: 79, strony: 1060-1067), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.33963/KP.a2021.0137 - link to the publication
  4. Towards Personalized Therapy of Aortic Stenosis
    Authors:
    Piotr Mazur, Magdalena Kopytek, Michał Ząbczyk, Anetta Undas, Joanna Natorska
    Academic press:
    Journal of Personalized Madicine (rok: 2021, tom: 11, strony: 1292), Wydawca: MDPI
    Status:
    Published
    DOI:
    0.3390/jpm11121292. - link to the publication
  5. Valvular expression of factor XI correlates with valve calcification and aortic stenosis severity
    Authors:
    Kopytek M, Konstanty-Kalandyk J, Ząbczyk M, Undas A, Natorska J.
    Academic press:
    Kardiol Pol (rok: 2023, tom: 81, strony: 1269-1271), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.33963/v.kp.97723 - link to the publication
  1. Rywaroksaban osłabia zapalenie w obrębie stenotycznych zastawek u pacjentów ze stenozą aortalną
    Authors:
    Kopytek M, Ząbczyk M, Undas A, Natorska J
    Conference:
    25th International Congress of the Polish Cardiac Society (rok: 2021, ), Wydawca: Kardiologia Polska
    Data:
    konferencja 22.09-02.10
    Status:
    Published
  2. Rivaroxaban attenuates valvular calcification in patients with severe aortic stenosis
    Authors:
    M. Zabczyk, M. Kopytek, J. Tarasiuk, S. Wronski, A. Undas, J. Natorska
    Conference:
    European Atherosclerosis Society Congress (rok: 2022, ), Wydawca: Science Direct
    Data:
    konferencja 22-25.05
    Status:
    Published

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