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Information of the project and the call

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Tunneling nanotubes (TNTs) within the leukemia microenvironment; influence of metabolic remodeling and implications for therapy.

2018/29/B/NZ3/01778

Keywords:

stroma bone marrow niche leukemia leukemia microenvironment tunneling nanotubes TNTs metabolism adaptation therapy resistance

Descriptors:

  • NZ3_1:
  • NZ3_2:
  • NZ3_7:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Piwocka 

Number of co-investigators in the project: 7

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 769 800 PLN

Project start date (Y-m-d): 2019-04-01

Project end date (Y-m-d): 2023-03-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (12)
  • Book publications / chapters in book publications (2)
  1. Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells
    Authors:
    Kolba MD, Dudka W, Zaręba-Kozioł M, Kominek A, Ronchi P, Turos L, Chroscicki P, Wlodarczyk J, Schwab Y, Klejman A, Cysewski D, Srpan K, Davis DM, Piwocka K
    Academic press:
    Cell Death & Disease (rok: 2019, tom: 10, strony: 817), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41419-019-2045-8 - link to the publication
  2. Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function
    Authors:
    Laura Turos-Korgul, Marta Dorota Kolba, Piotr Chroscicki, Aleksandra Zieminska, Katarzyna Piwocka
    Academic press:
    Front Cell Dev Biol. (rok: 2022, tom: 10, strony: 45670), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2022.915117 - link to the publication
  1. Bone marrow stromal protective microenvironment in leukemia: metabolic plasticity and resistance driven by direct intercellular transfer of vesicles and proteins
    Authors:
    Piotr Chrościcki, Nikodem Kasak, Laura Turos-Korgul, Dominik Cysewski, Dorota Dymkowska, Krzysztof Zabłocki, Katarzyna Piwocka
    Conference:
    EACR Conference: The Tumour Ecosystem: Cellular Interactions and Therapeutic Opportunities (rok: 2024, ), Wydawca: EACR
    Data:
    konferencja 19 - 21 March 2024
    Status:
    Published
  2. Multifunctional role of stroma-derived CD44 protein in reprogramming of chronic myeloid leukemia cells
    Authors:
    L. Turos-Korgul, A.Zieminska, J. janiec, D. Muhkaerje, M. Rudzinska-Radecka, J. Guzowski, K. Piwocka
    Conference:
    EACR Cancer Metabolism (rok: 2024, ), Wydawca: EACR
    Data:
    konferencja 8-10.10.2024, Bilbao, Spain
    Status:
    Published
  3. No cell is an island - - the role of stromal-derived CD44 protein in the development of drug resistance in leukemia cells
    Authors:
    Laura Turos-Korgul, Aleksandra Ziemińska, Laurie Parker, Katarzyna Piwocka
    Conference:
    6th PhD Student Conference at Nencki Institute of Experimental Biology PAS (rok: 2022, ), Wydawca: Nencki Institute
    Data:
    konferencja 17-18.10.2022
    Status:
    Published
  4. Bone marrow stromal cells upregulate Oxphos pathway in CML cells via direct leukemia-stroma interactions
    Authors:
    Piotr Chroscicki, Marta D. Kolba, Laura Turos, Agata Kominek, Monika Zareba-Koziol, Dominik Cysewski, Dorota Dymkowska, Magdalena Lebiedzinska-Arciszewska, Agata Klejman, Jakub Wlodarczyk, Mariusz R. Wieckowski, Katarzyna Piwocka
    Conference:
    23rd Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy (rok: 2021, ), Wydawca: ESH
    Data:
    konferencja 7-10.10.2021
    Status:
    Published
  5. . Investigating the role of cell adhesion molecules in tunneling nanotubes formation in chronic myeloid leukemia microenvironment
    Authors:
    Turos-Korgul L., Zieminska A., Parker L., Piwocka K.
    Conference:
    European Hematology Association Congress (rok: 2022, ), Wydawca: EHA
    Data:
    konferencja 9-12.06.2022, Wiedeń
    Status:
    Published
  6. No cell is an island";: unveiling the secrets of stroma- leukemia communication and its pro-leukemic impact (Poster- Awarded) in Best Poster Competitoon
    Authors:
    L. Turos-Korgul, A. Zieminska, A. Kominek, K. Piwocka
    Conference:
    Young Scientists' Forum 2.0, (rok: 2024, ), Wydawca: Wielkopolskie Centrum Onkologii Poznań
    Data:
    konferencja 06.12.2024
    Status:
    Published
  7. Investigating the role of CD44 cell adhesion molecule in tunneling nanotube formation in chronic myeloid leukemia microenvironment
    Authors:
    Laura Turos-Korgul, Aleksandra Ziemińska and Katarzyna Piwocka
    Conference:
    5th PhD Student Conference at Nencki Institute of Experimental Biology PAS (rok: 2021, ), Wydawca: Nencki Institute
    Data:
    konferencja 14-15.10.2021
    Status:
    Published
  8. TNT-mediated transfer of mitochondria between cells in leukemic bone marrow niche.
    Authors:
    Piotr Chroscicki, Marta Dorota Kolba, Agata Kominek, Laura Turos, Dominik Cysewski, Katarzyna Piwocka
    Conference:
    EMBO Workshop Molecular mechanisms of unconventional protein secretion in eukaryotic cells (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 2019-08-16; Asisi, Italy
    Status:
    Published
  9. Multifunctional role of stroma-derived CD44 protein in reprogramming of chronic myeloid leukemia cells
    Authors:
    L. Turos-Korgul, A. Zieminska, J. Janiec, D. Mukherjee, M. Rudzinska-Radecka, J. Guzowski, K. Piwocka
    Conference:
    EACR Conference: The Tumour Ecosystem: Cellular Interactions and Therapeutic Opportunities, (rok: 2024, ), Wydawca: EACR
    Data:
    konferencja 19-21.03.2024
    Status:
    Published
  10. Unveiling the secrets of stroma-leukemia communication and its pro-leukemic impact: focus on CD44 protein. (Wystąpienie ustne)
    Authors:
    L. Turos-Korgul, A. Zieminska, J. Ostrowska, Z. Dabrowska, N. Kasak, S. de Biasi, A. Cossarizza, K. Piwocka
    Conference:
    VI Zjazd Naukowy Polskiego Towarzystwa Biologii Medycznej BIOLOGIA-MEDYCYNA- TERAPIA. (rok: 2024, ), Wydawca: Polskie Towarzystwo Biologii Medycznej
    Data:
    konferencja 19-21.09.2024
    Status:
    Published
  11. Tunneling nanotube-mediated transfer of CD44 protein from stromal to leukemic cells promotes increased drug efflux and chemoresistance
    Authors:
    Turos-Korgul L, Kolba M, Kominek A, Parker L, Piwocka K.
    Conference:
    Congress of International Society for Advancement of Cytometry CYTO Virtual 2021 (rok: 2021, ), Wydawca: ISAC
    Data:
    konferencja 7-10.06.2021
    Status:
    Published
  12. THE PHENOMENON OF TNT-MEDIATED CD44 PROTEIN TRANSFER FROM STROMAL TO LEUKEMIC CELLS AND ITS EFFECT ON DRUG RESISTANCE
    Authors:
    Laura Turos-Korgul, Aleksandra Zieminska, Jakub Janiec, Laurie Parker, Katarzyna Piwocka
    Conference:
    ESH MICRO 2023 - 4th Scientific Workshop: the Haematological Tumour Microenvironment and its Therapeutic Targeting (rok: 2023, ), Wydawca: ESH
    Data:
    konferencja 05-07.02.2023
    Status:
    Published
  1. Cell metabolism: Functional and phenotypic single cell approaches
    Authors:
    ara De Biasi, Julien Paul Gigan, Rebecca Borella, Elena Santacroce, Domenico Lo Tartaro, Anita Neroni, Nikolaos Paschalidis , Katarzyna Piwocka , Rafael J. Argüello , Lara Gibellini, Andrea Cossarizza
    Book:
    Methods in Cell Biology (rok: 2024, tom: 186, strony: 151-187), Wydawca: Elsevier
    Status:
    Published
  2. Cell Metabolism: functional and phenotypic single cell approaches
    Authors:
    Sara De Biasi, Julien Paul Gigan, Rebecca Borella, Elena Santacroce, Domenico Lo Tartaro, Anita Neroni, Nikolaos Paschalidis , Katarzyna Piwocka , Rafael J. Argüello , Lara Gibellini, Andrea Cossarizza
    Book:
    Status:
    Accepted for publication

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