Projects funded by the NCN

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Biological study and mathematical modeling to describe and predict new processes controlling the development, function and atresia of ovarian follicles in cows

2018/29/B/NZ9/00391

Keywords:

follicles IGF-1 garnulosa necroptosis mathematical modeling cow

Descriptors:

  • NZ9_2: Animal production
  • NZ2_8: Computational biology
  • NZ4_6: Endocrinology

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dariusz Skarżyński 

Number of co-investigators in the project: 10

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 966 000 PLN

Project start date (Y-m-d): 2019-01-24

Project end date (Y-m-d): 2024-12-23

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (6)
  • Book publications / chapters in book publications (1)
  1. Effects of prostaglandin F2α on cell-death pathways in the bovine corpus luteum.
    Authors:
    Jonczyk AW, Piotrowska-Tomala KK, Skarzynski DJ.
    Academic press:
    BMC Veterinary Research (rok: 2019, tom: 5(1), strony: 416 (16 stron)), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12917-019-2167-3 - link to the publication
  2. Apoptosis, autophagic cell death, and necroptosis: different types of programmed cell death in bovine corpus luteum regression.
    Authors:
    Hojo T, Skarzynski DJ, Okuda K.
    Academic press:
    Journal of Reproduction and Develpment (rok: 2022, tom: 68, strony: 355–360), Wydawca: Society for Reproduction and Development
    Status:
    Published
    DOI:
    10.1262/jrd.2022-097. - link to the publication
  3. Death processes in bovine theca and granulosa cells modelled and analysed using a systems biology approach
    Authors:
    McEvoy MJ, Sinderewicz E, Creedon L, McAfee M, Jończyk AW, Piotrowska-Tomala KK, Skarżyński DJ.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22/9, strony: art no 4888, strony: 1-8), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094888 - link to the publication
  1. Apoptosis, autophagy, necroptosis and ferroptois: the many faces of programmed cell death in the bovine ovary (invitation lecture)
    Authors:
    Skarzynski DJ, Hojo T, Moza Jalali B, Jonczyk AW, McEvoy M, Piotrowska-Tomala KK, Okuda K.
    Conference:
    SSR 56th Annual Meeting: Reproductive Sciences - From Innovation to Impact. Shaw Centre, Ottawa, Canada (rok: 2023, ), Wydawca: SSR
    Data:
    konferencja 11-14. July 2023
    Status:
    Published
  2. Functional connections within steroidogenic pathway in primary cultures of bovine granulosa cells investigated with PPI and co-expression networks.
    Authors:
    Skarzynski D, Wieteska M, Hession JA, Piotrowska-Tomala KK, Jonczyk A, Kordowitzki P, Lukasik K, Creedon L
    Conference:
    52nd SSR Annual Conference San Jose, USA. (rok: 2019, ), Wydawca: Society for the Study of Reproduction
    Data:
    konferencja 2019-07-18-21
    Status:
    Published
  3. Pharmacokinetic and Pharmacodynamic In Vivo Model of IGF-1 in Dairy Cows and its Effect on Estradiol and Progesterone Production
    Authors:
    McEvoy MJ, McAfee M, Hughes K, Piotrowska-Tomala, KK, Jonczyk A, Kordowitzki P, Lukasik K, Creedon L, Skarzynski DJ.
    Conference:
    SSR 54th Annual Meeting Dec.15-18, 2021 St. Louis, MO, USA. (rok: 2021, ), Wydawca: Society for the Study of Reproduction
    Data:
    konferencja 12 - 15. XII
    Status:
    Published
  4. A MATHEMATICAL MODEL OF ESTRADIOL PRODUCTION IN BOVINE OVARIAN FOLLICLES
    Authors:
    McEvoy M.J, Butler S.T., Hession J.A. and Creedon L.
    Conference:
    12th Conference on Dynamical Systems Applied to Biology and Natural Sciences (rok: 2021, ), Wydawca: European Society for Mathematical and Theoretical Biology
    Data:
    konferencja 2 - 5 February 2021
    Status:
    Published
  5. Mathematical modelling as a tool to describe development of bovine ovarian follicles
    Authors:
    McEvoy M.J., McEvoy M., Lukasik K., Skarzynski D.J, Creedon L.
    Conference:
    11th International Ruminant Reproduction Symposium (IRRS 2023) Galway, Ireland (rok: 2023, ), Wydawca: Elsevier
    Data:
    konferencja 28 May-1 June 2023
    Status:
    Published
  6. Necroptosis in bovine follicles and granulosa cells cultured in vitro.
    Authors:
    Lukasik K, Likszo P, Baclawska A, Moza Jalali B, Skarzynski D.J.
    Conference:
    11th International Ruminant Reproduction Symposium (IRRS 20230 Galway, Ireland (rok: 2023, ), Wydawca: Elsevier
    Data:
    konferencja 28 May-1 June 2023
    Status:
    Published
  1. Linear Dynamics of mRNA Expression and Hormone Concentration Levels in Primary Cultures of Bovine Granulosa Cells.
    Authors:
    Wieteska MJ, , Hession JA., Piotrowska-Tomala KK, Jonczyk A, Kordowitzki P, Lukasik K, Skarzynski DJ, Creedon L.
    Book:
    Current Trends in Dynamical Systems in Biology and Natural Sciences. SEMA SIMAI Springer Series 21 (rok: 2020, tom: 21, strony: 223-243), Wydawca: Springer Nature Switzerland AG
    Status:
    Published

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