Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms of removal of neutrophil extracellular traps (NETs) from vasculature: an intravital microscopy approach

2018/29/B/NZ6/00713

Keywords:

neutrophils neutrophil extracellular traps sepsis intravital microscopy

Descriptors:

  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta Kołaczkowska 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 869 600 PLN

Project start date (Y-m-d): 2019-01-31

Project end date (Y-m-d): 2023-01-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora laminarna mikrobiologiczna (15 913 PLN)
  2. Łaźnia wodna (2 253 PLN)
  3. "Poczwórna kostka filtrów fluorescencji oraz dodatkowe pojedyncze filtry fluorescencji kompatybilne z Andor spinning-disk DSD2" (85 000 PLN)
  4. Komora laminarna II klasy bezpieczeństwa. (29 150 PLN)
  5. "Mikroskop z nieruchomym stolikiem i obiektywami o dużej odległości roboczej do podłączenia do posiadanego modułu konfokalnego spinning-disk DSD2 Andor" (190 000 PLN)
  6. Inkubator CO2 (37 810 PLN)
  7. Zamrażarka niskotemperaturowa (29 089 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): Involvement of Hypoxia-Inducible Factor 1α (Hif-1α) and Heme Oxygenase (HO-1)
    Authors:
    Gabriela Burczyk, Iwona Cichon , Elzbieta Kolaczkowska
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 864638), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.864638 - link to the publication
  2. Reduced Neutrophil Extracellular Trap (NET) Formation During Systemic Inflammation in Mice With Menkes Disease and Wilson Disease: Copper Requirement for NET Release
    Authors:
    Iwona Cichon, Weronika Ortmann, Aleksandra Bednarz, Malgorzata Lenartowicz and Elzbieta Kolaczkowska
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 10, strony: 45308), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.03021 - link to the publication
  3. On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
    Authors:
    Santocki M, Kolaczkowska E
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 2079), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9092079 - link to the publication
  4. Patients with COVID-19: in the dark-NETs of neutrophils
    Authors:
    Maximilian Ackermann , Hans-Joachim Anders, Rostyslav Bilyy, Gary L Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J Kaplan, Jason S Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitroulis, Luis E Muñoz, Teluguakula Narasaraju, Elisabeth Naschberger, Indira Neeli , Lai Guan Ng , Marko Z Radic, Konstantinos Ritis, Patrizia Rovere-Querini, Mirco Schapher, Christine Schauer, Hans-Uwe Simon, Jeeshan Singh, Panagiotis Skendros, Konstantin Stark, Michael Stürzl, Johan van der Vlag, Peter Vandenabeele, Ljubomir Vitkov, Maren von Köckritz-Blickwede, Cansu Yanginlar, Shida Yousefi, Alexander Zarbock, Georg Schett, Martin Herrmann
    Academic press:
    Cell Death & Differentiation (rok: 2021, tom: 28, strony: 3125-3139), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41418-021-00805-z - link to the publication
  5. Editorial: Intravital Microscopy Imaging of Leukocytes
    Authors:
    Wong CHY, Jenne CN, Kolaczkowska E.
    Academic press:
    Front Immunol. (rok: 2020, tom: 11, strony: 2137), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.02137 - link to the publication

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