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Contribution of PHLDA1 to response of neuroblastoma cells to clinical and experimental ways of treatment of high-risk neuroblastoma

2018/29/B/NZ7/01564

Keywords:

PHLDA1 neuroblastoma mice anti GD2 ganglioside-recognizing antibodies

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ1_1: Molecular biology
  • NZ3_7: Signal transduction

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hanna Rokita 

Number of co-investigators in the project: 6

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 342 400 PLN

Project start date (Y-m-d): 2019-01-28

Project end date (Y-m-d): 2024-01-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. The extracellular matrix and neuroblastoma cell communication - a complex interplay and its therapeutic implications
    Authors:
    Irena Horwacik
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 3172), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11193172 - link to the publication
  2. Silencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells
    Authors:
    Beata Bugara, Małgorzata Durbas, Maja Kudrycka, Agata Malinowska, Irena Horwacik, Hanna Rokita
    Academic press:
    Frontiers in Pharmacology (rok: 2024, tom: 15, strony: 45673), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10 - link to the publication
  3. Apoptosis is responsible for cytotoxic effects of anti-GD2 ganglioside antibodies and aurora A kinase inhibitors on human neuroblastoma cells
    Authors:
    Małgorzata Durbas, Hanna Rokita, Irena Horwacik, Aneta Wiśniewska, Iwona Nowak
    Academic press:
    Acta Biochimica Polonica (rok: 2022, tom: 69, strony: 485-494), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics of Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2020-6344 - link to the publication

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