Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Hypoxia inducible factor alpha (Hif-1 alpha) and transcription factor Foxn1 guide regenerative vs reparative skin wound healing processes

2017/27/B/NZ5/02610

Keywords:

Foxn1 Hif-1 alpha regeneration skin wound healing

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_4: Pathogenesis of animal diseases
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Barbara Gawrońska-Kozak 

Number of co-investigators in the project: 12

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 994 940 PLN

Project start date (Y-m-d): 2018-08-10

Project end date (Y-m-d): 2023-02-09

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do dekontaminacji inkubatorów.
  2. Aparat fotograficzny z obiektywem (6 000 PLN)
  3. Countess II - licznik komorek.
  4. Kostka z filtrami do fluorescencji.
  5. Multiskan - czytnik mikropłytek.
  6. laptop wraz z oprogramowamiem (Graph Pad Prizm, EndNote) (2 szt.) (15 000 PLN)
  7. zestaw pipet (2 szt.) (7 000 PLN)
  8. Inkubator (52 000 PLN)
  9. Zestaw do analizy metodą Western Blot (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Age, Diet and Epidermal Signaling Modulate Dermal Fibroblasts' Adipogenic Potential
    Authors:
    Katarzyna Walendzik, Joanna Bukowska, Marta Kopcewicz, Sylwia Machcinska, Jeffrey M. Gimble, Barbara Gawronska-Kozak
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21 (23), strony: art. no 8955 (1-19)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21238955 - link to the publication
  2. Cutaneous wound healing in aged, high fat diet-induced obese female or male C57BL/6 mice
    Authors:
    Kopcewicz, M.; Walendzik, K.; Bukowska, J.; Kur-Piotrowska, A.; Machcinska, S.; Gimble, J.M.; Gawronska-Kozak, B
    Academic press:
    Aging-US (rok: 2020, tom: 12, strony: 7066-7111), Wydawca: Albany NY
    Status:
    Published
    DOI:
    10.18632/aging.103064 - link to the publication
  3. Molekularne mechanizmy działania czynnika transkrypcyjnego FOXN1 w skórze
    Authors:
    Barbara Gawrońska-Kozak, Anna Kur-Piotrowska, Joanna Wiśniewska, Marta Kopcewicz
    Academic press:
    Postępy HIgieny i Medycyny Doświadczalnej (rok: 2021, tom: 75, strony: 573-583), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/ahem-2021-0028 - link to the publication
  4. Impairment of the Hif-1α regulatory pathway in Foxn1-deficient (Foxn1-/- ) mice affects the skin wound healing process
    Authors:
    Machcinska S, Kopcewicz M, Bukowska J, Walendzik K, Gawronska-Kozak B.
    Academic press:
    FASEB Journal (rok: 2021, tom: 35, strony: 45313), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202001907R - link to the publication
  5. The transcription factor Foxn1 regulates skin adipogenesis and affects susceptibility to diet-induced obesity
    Authors:
    Katarzyna Walendzik, Marta Kopcewicz, Joanna Bukowska, Grzegorz Panasiewicz, Bozena Szafranska and Barbara Gawronska-Kozak
    Academic press:
    Journal of Investigative Dermatology (rok: 2020, tom: June; 140 (6), strony: 1166-1175), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jid.2019.11.010 - link to the publication
  6. Dermal White Adipose Tissue (dWAT) Is Regulated by Foxn1 and Hif-1 during the Early Phase of Skin Wound Healing
    Authors:
    Barbara Gawronska-Kozak, KatarzynaWalendzik , Sylwia Machcinska , Artur Padzik, Marta Kopcewicz and Joanna Wisniewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23, strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010257 - link to the publication
  7. Foxn1 Control of Skin Function
    Authors:
    Gawronska-Kozak Barbara
    Academic press:
    Applied Sciences Basel (rok: 2020, tom: 10, strony: art. no 5685 (1-12)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app10165685 - link to the publication
  8. Hypoxia reveals a new function of Foxn1 in the keratinocyte antioxidant defence system
    Authors:
    Machcinska S., Walendzik K., Kopcewicz M., Wisniewska J., Rokka A., Pääkkönen M., Slowinska M., Gawronska-Kozak B.
    Academic press:
    FASEB Journal (rok: 2022, tom: 36, strony: 45316), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202200249RR - link to the publication

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