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Epigenetic regulation of lipolysis in cardiomyocytes in hypoxia and normoxia - the role of stearoyl-CoA desaturase

2017/27/N/NZ4/01995

Keywords:

lipid metabolism cardiomyocytes epigenetics hypoxia ATGL HSL

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_2: Physiology
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Adam Olichwier 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 139 200 PLN

Project start date (Y-m-d): 2018-07-26

Project end date (Y-m-d): 2021-07-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes
    Authors:
    Adam Olichwier, Adrian Sowka, Volodymyr V Balatskyi, Ana-Maria Gan, Anna Dziewulska, Pawel Dobrzyn
    Academic press:
    Biochimica et Biophysica Acta: Molecular Cell Research (rok: 2024, tom: 1871(1), strony: 119608), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2023.119608 - link to the publication
  2. Interplay between Thyroid Hormones and Stearoyl-CoA Desaturase 1 in the Regulation of Lipid Metabolism in the Heart
    Authors:
    Adam Olichwier, Volodymyr V Balatskyi, Marcin Wolosiewicz, James M Ntambi, Pawel Dobrzyn
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 22(1), strony: 109), Wydawca: MDPI journals
    Status:
    Published
    DOI:
    10.3390/ijms22010109 - link to the publication
  3. β-Catenin Regulates Cardiac Energy Metabolism in Sedentary and Trained Mice
    Authors:
    Volodymyr V Balatskyi, Oksana L Palchevska, Lina Bortnichuk, Ana-Maria Gan, Anna Myronova, Larysa L Macewicz, Viktor O Navrulin, Lesya V Tumanovska, Adam Olichwier, Pawel Dobrzyn, Oksana O Piven
    Academic press:
    Life (Basel, Switzerland) (rok: 2020, tom: 10(12), strony: 357), Wydawca: MDPI journals
    Status:
    Published
    DOI:
    10.3390/life10120357 - link to the publication
  1. Hypoxia affects lipid metabolism and epigenetic modifications in cardiomyocytes - role of adipose triglyceride lipase (ATGL)
    Authors:
    A. Olichwier, A.M. Gan, P. Dobrzyn
    Conference:
    44th Congress of the Federation of European Biochemical Societies (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 43652
    Status:
    Published
  2. Loss of stearoyl-CoA desaturase 1 affects thyroid hormnoe action and induces epigenetic modifications in cardiomyocytes
    Authors:
    A. Olichwier  , P. Dobrzyń 
    Conference:
    42nd Annual Meeting of the European Thyroid Association (rok: 2019, ), Wydawca: European Thyroid Journal & Karger AG, Basel
    Data:
    konferencja 43715
    Status:
    Published
  3. Role of stearoyl-CoA desaturase 1 in control of the heart function through lipid metabolism changes in hyperthyroidism
    Authors:
    A. Olichwier, A. Bińczak, M. Duda, P. Dobrzyń.
    Conference:
    XXVIII Congress of the Polish Physiological Society (rok: 2021, ), Wydawca: Polskie Towarzystwo Fizjologiczne
    Data:
    konferencja 42993
    Status:
    Published

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