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Understanding the molecular basis of the regulation of activity of lysosome, a potential target of therapeutic intervention in inflammatory skin diseases, using psoriasis as a model

2017/27/B/NZ3/02212

Keywords:

lysosome signaling pathways inflammation autoimmune skin diseases psoriasis

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology
  • NZ5_7: Human disease treatment

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Magdalena Gabig-Cimińska 

Number of co-investigators in the project: 7

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 999 400 PLN

Project start date (Y-m-d): 2018-07-26

Project end date (Y-m-d): 2024-01-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Lysosome alterations in the human epithelial cell line HaCaT and skin specimens: relevance to psoriasis
    Authors:
    Bocheńska, K., Moskot, M., Malinowska, M., Jakóbkiewicz-Banecka, J., Szczerkowska-Dobosz, A., Purzycka-Bohdan, D., Pleńkowska, J., Słomiński, B., Gabig-Cimińska, M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 2255-2278), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20092255 - link to the publication
  2. Genistein modulates gene activity in psoriatic patients
    Authors:
    Smolińska, E., Węgrzyn, G., Gabig-Cimińska, M.
    Academic press:
    Acta Biochimica Polonica (rok: 2019, tom: 66, strony: 101-110), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2018_2772 - link to the publication
  3. Oxidative stress as an important contributor to the pathogenesis of psoriasis
    Authors:
    Pleńkowska, J., Gabig-Cimińska, M., Mozolewski, P.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 6206-6221), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176206 - link to the publication
  4. Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
    Authors:
    Bocheńska, K., Moskot, M., Smolińska-Fijołek, E., Jakóbkiewicz-Banecka, J., Szczerkowska-Dobosz, A., Słomiński, B., Gabig-Cimińska, M.
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 18297-18311), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-97793-4 - link to the publication
  5. Insights into autophagic machinery and lysosomal function in cells involved in the psoriatic immune-mediated inflammatory cascade
    Authors:
    Kuczyńska, M., Moskot, M., Gabig-Cimińska, M.
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2024, tom: 14, strony: 1170273-1170283), Wydawca: de Gruyter Poland (Sciendo)
    Status:
    Published
    DOI:
    10.2478/aite-2024-0005 - link to the publication
  6. Use of cytokine mix-, imiquimod-, and serum-induced monoculture and lipopolysaccharide- and interferon gamma-treated co-culture to establish in vitro psoriasis-like inflammation models
    Authors:
    Bocheńska, K., Moskot, M., Gabig-Cimińska, M.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 2985-3005), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10112985 - link to the publication
  7. Molecular treatment trajectories within psoriatic T lymphocytes: a mini review
    Authors:
    Kuczyńska, M., Gabig-Cimińska, M., Moskot, M.
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 1170273-1170283), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1170273 - link to the publication
  8. Unbalanced sphingolipid metabolism and its implications for the pathogenesis of psoriasis
    Authors:
    Bocheńska, K., Gabig-Cimińska, M.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 1130-1150), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25051130 - link to the publication

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