Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Standardisation and biological activity of blackthorn flowers (Prunus spinosa L.) in the context of cardiovascular disease

2017/27/N/NZ7/02074

Keywords:

Prunus spinosa L. flowers polyphenols antioxidants blood plasma haemostasis cardiovascular disease standardisation

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Marchelak 

Number of co-investigators in the project: 3

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 209 940 PLN

Project start date (Y-m-d): 2018-07-31

Project end date (Y-m-d): 2023-07-30

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pipety elektroniczne.
  2. Automatyczna płuczka do płytek MPR (22 000 PLN)
  3. Mikrowaga (31 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Data on the optimization and validation of HPLC-PDA method for quantification of thirty polyphenols in blackthorn flowers and dry extracts prepared thereof
    Authors:
    Marchelak A., Olszewska M.A., Owczarek A.
    Academic press:
    Data in Brief (rok: 2020, tom: 29, strony: 105319), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dib.2020.105319 - link to the publication
  2. New insights into antioxidant activity of Prunus spinosa flowers: Extracts, model polyphenols and their phenolic metabolites in plasma towards multiple in vivo-relevant oxidants.
    Authors:
    Marchelak A., Owczarek A., Rutkowska M., Michel P., Kolodziejczyk-Czepas J., Nowak P., Olszewska M.A.
    Academic press:
    Phytochemistry Letters (rok: 2019, tom: 30, strony: 288-295), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phytol.2019.02.011 - link to the publication
  3. The effects of Prunus spinosa L. flower extracts, model polyphenols and phenolic metabolites on oxidative/nitrative modifications of human plasma components with particular emphasis on fibrinogen in vitro
    Authors:
    Anna Marchelak, Joanna Kołodziejczyk-Czepas, Paulina Wasielewska, Paweł Nowak, Monika Olszewska
    Academic press:
    Antioxidants (rok: 2021, tom: 10, strony: 45315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10040581 - link to the publication
  4. Simultaneous quantification of thirty polyphenols in blackthorn flowers and dry extracts prepared thereof: HPLC-PDA method development and validation for quality control
    Authors:
    Marchelak A., Olszewska M.A., Owczarek A.
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2020, tom: 184, strony: 113121), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2020.113121 - link to the publication
  5. Flavonol and A-type procyanidin-rich extracts of Prunus spinosa L. flower exhibit anticoagulant activity through direct thrombin inhibition, but do not affect platelet aggregation in vitro
    Authors:
    Marchelak A., Kolodziejczyk-Czepas J., Ponczek M.B., Liudvytska O., Markowicz-Piasecka M., Bielska B., Miłowska K., Olszewska M.A.
    Academic press:
    Frontiers in Pharmacology , Wydawca: Frontiers
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. A validated HPLC-PDA method for quantification of bioactive constituents in blackthorn flowers and dry extracts prepared thereof
    Authors:
    Marchelak A., Owczarek A., Olszewska M.A.
    Conference:
    4th International Conference on Natural Products Utilization From Plants to Pharmacy Shelf (rok: 2019, ), Wydawca: Department of Plant Cell Biotechnology and Metabolomics, The Stephan Angeloff Institute of Microbiology
    Data:
    konferencja 29.05-1.06.2019
    Status:
    Published
  2. FRAKCJONOWANE EKSTRAKTY Z KWIATÓW PRUNUS SPINOSA L. JAKO ŹRÓDŁO ZWIĄZKÓW POLIFENOLOWYCH HAMUJĄCYCH AKTYWNOŚĆ TROMBINY – BADANIA IN VITRO I IN SILICO
    Authors:
    Marchelak A., Kołodziejczyk-Czepas J., Ponczek M.B., Bielska B., Miłowska K., Olszewska M.A.
    Conference:
    XVI Kopernikańskie Seminarium Doktoranckie (rok: 2023, ), Wydawca: Wydział Chemii Uniwersytet Mikołaja Kopernika w Toruniu
    Data:
    konferencja 29-30.06.2023r.
    Status:
    Published

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