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Information on the principal investigator and host institution

Information of the project and the call

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Optimizing dialyzate bicarbonate concentration during hemodialysis by mathematical modeling

2017/27/B/ST7/03029

Keywords:

biomedical engineering artificial organs hemodialysis acid base equilibrium optimization mathematical modeling

Descriptors:

  • ST6_12: Scientific computing, simulation and modelling tools
  • NZ5_7: Human disease treatment
  • ST7_11: Electronic, optoelectronic and photonic components and systems for applications (e.g. in biomedical engineering)

Panel:

ST7 - Systems and communication engineering: electronics, communication, optoelectronics

Host institution :

Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. John Leypoldt 

Number of co-investigators in the project: 8

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 706 533 PLN

Project start date (Y-m-d): 2018-07-31

Project end date (Y-m-d): 2024-07-30

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Modeling acid-base balance during continuous kidney replacement therapy
    Authors:
    John K. Leypoldt, Mauro Pietribiasi, Jorge Echeverri, Kai Harenski
    Academic press:
    Journal of Clinical Monitoring and Computing (rok: 2022, tom: 36, strony: 179-189), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10877-020-00635-3 - link to the publication
  2. Modeling acid-base balance for in-series extracorporeal carbon dioxide removal and continuous venovenous hemofiltration devices
    Authors:
    John K. Leypoldt, Jörg Kurz. Jorge Echeverri, Markus Storr, Kai Harenski
    Academic press:
    Artificial Organs (rok: 2021, tom: 45, strony: 1036-1049), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/aor.13969 - link to the publication
  3. Targeting arterial partial pressure of carbon dioxide in acute respiratory distress syndrome patients using extracorporeal carbon dioxide removal
    Authors:
    John K. Leypoldt, Jörg Kurz, Jorge Echeverri, Markus Storr, Kai Harenski
    Academic press:
    Artificial Organs (rok: 2022, tom: 46, strony: 677-687), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/aor.14127 - link to the publication
  4. Validity of the hydrogen ion mobilisation model during hemodialysis with time-dependent dialysate bicarbonate concentrations
    Authors:
    Leypoldt JK, Pietribiasi M, Debowska M, Wieliczko, Twardowska-Kawalec M, Malyszko J, Waniewski J
    Academic press:
    International Journal of Artificial Organs (rok: 2023, tom: 46, strony: 507-513), Wydawca: SAGE Publications Inc
    Status:
    Published
    DOI:
    10.1177/03913988231179233 - link to the publication
  5. Effect of time-dependent dialysate bicarbonate concentrations on acid–base and uremic solute kinetics during hemodialysis treatments
    Authors:
    Monika Wieliczko, Malgorzata Twardowska-Kawalec, Malgorzata Debowska, Mauro Pietribiasi, Urszula Bialonczyk, Jacek Waniewski, John K. Leypoldt, Joanna Matuszkiewicz-Rowinska & Jolanta Malyszko
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 2321: 1-9), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-52757-2 - link to the publication
  6. Mathematical modelling of bicarbonate supplementation and acid-base chemistry in kidney failure patients on hemodialysis
    Authors:
    Mauro Pietribiasi, Jacek Waniewski, and John K. Leypoldt
    Academic press:
    PLOS ONE (rok: 2023, tom: 18, strony: 45310), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0282104 - link to the publication
  7. Modeling acid-base transport in hemodialyzers
    Authors:
    Mauro Pietribiasi, John K. Leypoldt
    Academic press:
    Biocybernetics and Biomedical Engineering (rok: 2021, tom: 41, strony: 1150-1161), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbe.2021.07.006 - link to the publication
  8. Optimizing serum total carbon dioxide concentration during short and nocturnal frequent hemodialysis using lactate as dialysate buffer
    Authors:
    John K. Leypoldt, Michael K. Kraus, Allan J. Collins
    Academic press:
    Hemodialysis international (rok: 2020, tom: 24, strony: 470-479), Wydawca: International Society for Hemodialysis
    Status:
    Published
    DOI:
    10.1111/hdi.12864 - link to the publication
  9. ACID-BASE KINETICS DURING HEMODIALYSIS USING BICARBONATE AND LACTATE AS DIALYSATE BUFFER BASES BASED ON THE H+ MOBILIZATION MODEL
    Authors:
    John K. Leypoldt, Mauro Pietribiasi, Anna Ebinger, Michael A. Kraus, Allan Collins, Jacek Waniewski
    Academic press:
    International Journal of Artificial Organs (rok: 2020, tom: 43, strony: 45299), Wydawca: SAGE journals
    Status:
    Published
    DOI:
    10.1177/0391398820906524 - link to the publication
  10. Profiled delivery of bicarbonate during weekly cycle of hemodialysis
    Authors:
    Mauro Pietribiasi, John K. Leypoldt, Malgorzata Debowska, Monika Wieliczko, Malgorzata Twardowska-Kawalec, Jolanta Malyszko, Jacek Waniewski
    Academic press:
    PLOS ONE , Wydawca: PLOS
    Status:
    Submitted
    DOI:
    brak - link to the publication

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