Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of Mcpip1 RNase in disrupted endothalial homeostasis accompanying nonalcoholic fatty liver disease.

2017/27/B/NZ5/01440

Keywords:

endothelium fatty liver inflammation RNase Mcpip1

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Jerzy Kotlinowski 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 212 400 PLN

Project start date (Y-m-d): 2018-06-29

Project end date (Y-m-d): 2022-08-28

Project duration:: 50 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. aparat do elektroforezy.
  2. autoklaw (6 836 PLN)
  3. chłodziarka do analizatora biochemicznego.
  4. homogenizator elektryczny (10 000 PLN)
  5. oprogramowanie do obróbki statystycznej (4 388 PLN)
  6. kołyska 2D (7 000 PLN)
  7. komora laminarna do hodowli komórkowej typu II (55 000 PLN)
  8. wirówka nablatowa (5 000 PLN)
  9. kuchenka mikrofalowa (399 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Diosmetin alleviates liver inflammation by improving liver sinusoidal endothelial cell dysfunction.
    Authors:
    Dariusz Żurawek, Natalia Pydyn, Piotr Major, Krzysztof Szade, Katarzyna Trzos, Edyta Kuś, Ewelina Pośpiech, Piotr Małczak, Dorota Radkowiak, Andrzej Budzyński, Stefan Chłopicki, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    The EMBO Journal , Wydawca: EMBO Press
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis
    Authors:
    Jerzy Kotlinowski, Tomasz Hutsch, Izabela Czyzynska-Cichon, Marta Wadowska, Natalia Pydyn, Agnieszka Jasztal, Agnieszka Kij, Ewelina Dobosz, Maciej Lech, Katarzyna Miekus, Ewelina Pośpiech, Mingui Fu, Jolanta Jura, Joanna Koziel, Stefan Chlopicki
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (rok: 2021, tom: 1867, strony: 166086), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2021.166086. - link to the publication
  3. Hepatic Mcpip1 regulates adaptation to food restriction in mice.
    Authors:
    Olga Mucha, Bozena Skupien-Rabian, Alicja Slota, Katarzyna Trzos, Bartosz Podlewski, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    Acta Biochimica Polonica (rok: 2023, tom: online ahead of print, strony: n/n), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2020_6819 - link to the publication
  4. Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts.
    Authors:
    Natalia Pydyn, Dariusz Żurawek, Joanna Kozieł, Edyta Kus, Kamila Wojnar-Lason, Agnieszka Jasztal, Mingui Fu, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    The FEBS Journal (rok: 2021, tom: 288, strony: 6563-6580), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/febs.16040 - link to the publication
  5. Selected transgenic murine models of human autoimmune liver diseases.
    Authors:
    Katarzyna Trzos, Natalia Pydyn, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    Pharmacological Reports (rok: 2022, tom: online, strony: online), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00351-y - link to the publication

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