Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Microrobots controlled by multifunctional optical tweezers for hyperthermia of primary cancer cells and spheroids

2017/27/B/ST7/01255

Keywords:

Luminescent up-converting nanoparticles up-conversion light-to-heat conversion remote thermometry optical tweezers computer generated holograms hyperthermia 3D primary tumor spheroids tumor micorenviroment colloidal functional nanomaterials remote temperature readout temperature sensors fluorescent pH sensors light to heat coversion heat distribution at nanoscale

Descriptors:

  • ST7_11: Electronic, optoelectronic and photonic components and systems for applications (e.g. in biomedical engineering)
  • ST7_12: Electrical energy production, distribution and application

Panel:

ST7 - Systems and communication engineering: electronics, communication, optoelectronics

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Sławomir Drobczyński 

Number of co-investigators in the project: 9

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 445 160 PLN

Project start date (Y-m-d): 2018-07-27

Project end date (Y-m-d): 2022-07-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr z chłodzonym elementem CCD (50 000 PLN)
  2. Inkubator O2 i CO2 do hodowli komórkowej (25 000 PLN)
  3. Mieszadło magnetyczne (10 000 PLN)
  4. Notebook.
  5. Tłumik wiązki laserowej (5 000 PLN)
  6. Kamera cyfrowa (40 000 PLN)
  7. Laser 1064 nm (90 000 PLN)
  8. Microsoft Office 2019 Pro.
  9. Rama odwróconego mikroskopu biologicznego (80 000 PLN)
  10. Adobe Illustrator. Licencja 2022 (1 179 PLN)
  11. Karta analogowo-cyfrowa (10 000 PLN)
  12. Przenośny mini-inkubator CO2.
  13. Adobe Illustrator.
  14. Układ skanujących galvano-zwierciadeł (2 szt.) (30 000 PLN)
  15. Zamrażarka laboratoryjna.

Information in the final report

  • Publication in academic press/journals (10)
  1. Differentiation of single lymphoma primary cells and normal B-cells based on their adhesion to mesenchymal stromal cells in optical tweezers
    Authors:
    Duś-Szachniewicz K., Drobczyński S., Woźniak M., Zduniak K., Ostasiewicz K., Ziółkowski P., Korzeniewska A., Agrawal A., Kołodziej P., Walaszek K. M., Bystydzieński Z., Rymkiewicz G.
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 45304), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-46086-y - link to the publication
  2. Proteomic-Based Analysis of Hypoxia- and Physioxia-Responsive Proteins and Pathways in Diffuse Large B-Cell Lymphoma
    Authors:
    Kamila Duś-Szachniewicz,Katarzyna Gdesz-Birula,Krzysztof Zduniak,Jacek R. Wiśniewski
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 10082025/1-10082025/26), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10082025 - link to the publication
  3. Single-Cell Biodetection by Upconverting Microspinners
    Authors:
    Ortiz-Rivero E., Prorok K., Skowicki M., Lu D., Bednarkiewicz A., Jaque D., Haro-González P.
    Academic press:
    Small (rok: 2019, tom: 15, strony: 45300), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/smll.201904154 - link to the publication
  4. Development and Characterization of 3D Hybrid Spheroids for the Investigation of the Crosstalk Between B-Cell Non-Hodgkin Lymphomas and Mesenchymal Stromal Cells
    Authors:
    Kamila Duś-Szachniewicz, Katarzyna Gdesz-Birula, Grzegorz Rymkiewicz
    Academic press:
    OncoTargets and Therapy (rok: 2022, tom: 15, strony: 683-697), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/OTT.S363994 - link to the publication
  5. Luminescence based temperature bio-imaging: Status, challenges, and perspectives
    Authors:
    Bednarkiewicz A., Drabik J.,Trejgis K., Jaque D., Ximendes E., Marciniak L.
    Academic press:
    Applied Physics Reviews (rok: 2021, tom: 8, strony: 011317-1 - 011317-54), Wydawca: AIP Publishing
    Status:
    Published
    DOI:
    10.1063/5.0030295 - link to the publication
  6. Optical vortex torque measured with optically trapped microbarbells
    Authors:
    Lamperska W., Masajada J., Drobczynski S., Wasylczyk P.
    Academic press:
    Applied Optics (rok: 2020, tom: 59, strony: 4703-4707), Wydawca: The Optical Society of America
    Status:
    Published
    DOI:
    10.1364/AO.385167 - link to the publication
  7. Standardizing luminescence nanothermometry for biomedical applications
    Authors:
    Artur Bednarkiewicz, Lukasz Marciniak, Luís D. Carlos, Daniel Jaque
    Academic press:
    Nanoscale (rok: 2020, tom: 12, strony: 14405–14421), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0nr03568h - link to the publication
  8. Fluorescent ionic liquid micro reservoirs fabricated by dual-step E-beam patterning
    Authors:
    Dominik Kowal ,Krzysztof Rola,Joanna Cybinska,Marcin Skorenski,Adrian Zajac,Andrea Szpecht,Marcin Smiglak,Slawomir Drobczynski,Karolina Ciesiolkiewicz,Katarzyna Komorowska
    Academic press:
    Materials Research Bulletin (rok: 2021, tom: 142, strony: 111434/1-111434/8), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.materresbull.2021.111434 - link to the publication
  9. Formation of Lymphoma Hybrid Spheroids and Drug Testing in Real Time with the Use of Fluorescence Optical Tweezers
    Authors:
    Kamila Duś-Szachniewicz, Katarzyna Gdesz-Birula, Emilia Nowosielska, Piotr Ziółkowski, Sławomir Drobczyński
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11132113 - link to the publication
  10. Predicting the impact of temperature dependent multi-phonon relaxation processes on the photon avalanche behavior in Tm3+: NaYF4 nanoparticles
    Authors:
    Marcin Szalkowski,Magdalena Dudek,Zuzanna Korczak,Changhwan Lee,Łukasz Marciniak,Emory M. Chan, P. James Schuck,Artur Bednarkiewicz
    Academic press:
    Optical Materials: X (rok: 2021, tom: 12, strony: 100102/1-100102/8), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omx.2021.100102 - link to the publication

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