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Biochemical characterization of human SETD3 methyltransferase

2017/27/B/NZ1/00161

Keywords:

Human biochemical characterization methyltransferase SETD3 actin-specific histidine N-methyltransferase

Descriptors:

  • NZ1_2:
  • NZ1_1:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jakub Drożak 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 614 820 PLN

Project start date (Y-m-d): 2018-07-24

Project end date (Y-m-d): 2023-07-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis
    Authors:
    Nurgül Bilgin, Laust Moesgaard, Marijn N Maas, Jordi C J Hintzen, Apolonia Witecka, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović
    Academic press:
    Organic and Biomolecular Chemistry (rok: 2022, tom: 20, strony: 1723-1730), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1ob02430b - link to the publication
  2. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin
    Authors:
    Hintzen JCJ, Ma H, Deng H, Witecka A, Andersen SB, Drozak J, Guo H, Qian P, Li H, Mecinović J
    Academic press:
    Protein science (rok: 2022, tom: 31(5), strony: e4305.), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/pro.4305 - link to the publication
  3. Protein Histidine Methylation
    Authors:
    Kwiatkowski Sebastian, Drozak Jakub
    Academic press:
    Current Protein & Peptide Science (rok: 2020, tom: 21(7), strony: 675-689), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1389203721666200318161330 - link to the publication
  4. The structure, Activity, and Function of the SETD3 Protein Histidine Methyltransferase
    Authors:
    Apolonia Witecka, Sebastian Kwiatkowski, Takao Ishikawa, Jakub Drozak
    Academic press:
    Life (Basel) (rok: 2021, tom: 11, strony: 1040), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/life11101040 - link to the publication
  5. β-Actin Peptide-Based Inhibitors of Histidine Methyltransferase SETD3
    Authors:
    Jordi C J Hintzen, Laust Moesgaard, Sebastian Kwiatkowski, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović
    Academic press:
    ChemMedChem (rok: 2021, tom: 16, strony: 2695-2702), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/cmdc.202100296 - link to the publication
  6. Structural insights into SETD3-mediated histidine methylation on b-actin
    Authors:
    Qiong Guo, Shanhui Liao, Sebastian Kwiatkowski, Weronika Tomaka, Huijuan Yu, Gao Wu, Xiaoming Tu, Jinrong Min, Jakub Drozak, Chao Xu
    Academic press:
    eLife (rok: 2019, tom: 8, strony: e43676), Wydawca: eLife Sciences Publications
    Status:
    Published
    DOI:
    10.7554/eLife.43676 - link to the publication
  7. The role of Trp79 in β-actin on histidine methyltransferase SETD3 catalysis
    Authors:
    Mays Al-Fakhar, Nurgül Bilgin, Laust Moesgaard, Apolonia Witecka, Jakub Drozak, Jacob Kongsted, Jasmin Mecinovic
    Academic press:
    ChemBioChem (rok: 2023, tom: e202300490, strony: 45664), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/cbic.202300490 - link to the publication
  8. The role of Trp79 in β-actin on histidine methyltransferase SETD3 catalysis
    Authors:
    Mays Al-Fakhar, Nurgül Bilgin, Laust Moesgaard, Apolonia Witecka, Jakub Drozak, Jacob Kongsted, Jasmin Mecinovic
    Academic press:
    ChemBioChem (rok: 2023, tom: e202300490, strony: 45664), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/cbic.202300490 - link to the publication

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