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Role of TBC1D5 phosphorylation in neurodevelopment and TSC-related cell pathology

2017/27/B/NZ3/01358

Keywords:

TBC1D5 mTOR retromer neurogenesis TSC

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Jaworski 

Number of co-investigators in the project: 7

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 795 700 PLN

Project start date (Y-m-d): 2018-07-02

Project end date (Y-m-d): 2022-06-01

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning
    Authors:
    Janusz-Kaminska, Jaworski J.
    Academic press:
    Autophagy Reports (rok: 2024, tom: 3:1, 2346064, strony: 45661), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/27694127.2024.2346064 - link to the publication
  2. Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner
    Authors:
    Janusz-Kaminska A, Brzozowska A, Tempes A, Urbanska M, Blazejczyk M, Miłek J, Kuzniewska B, Zeng J, Wesławski J, Kisielewska K, Bassell GJ, Jaworski J.
    Academic press:
    Mol Biol Cell. (rok: 2024, tom: 35(3):ar43, strony: 45677), Wydawca: ACSB
    Status:
    Published
    DOI:
    10.1091/mbc.E23-02-0060 - link to the publication
  3. Pathological mTOR mutations impact cortical development.
    Authors:
    Tarkowski B, Kuchcinska K, Blazejczyk M, Jaworski J.
    Academic press:
    Human Molecular Genetics (rok: 2019, tom: 28(13), strony: 2107-2119), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/hmg/ddz042 - link to the publication
  4. mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types
    Authors:
    Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska , Jacek Jaworski
    Academic press:
    Cell Mol Biol Lett . (rok: 2021, tom: 26, strony: 45675), Wydawca: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s11658-021-00262-z - link to the publication
  5. mTOR-dependent phosphorylation of TBC1D5 is essential for neuronal morphogenesis and autophagic lysosomal reformation
    Authors:
    Oliver Tkaczyk, Magdalena Blazejczyk, Magdalena Mlostek, Katarzyna Kisielewska, Jan Weslawski, Kinga Kuchcinska, Agnieszka Brzozowska, Justyna Zmorzynska, Maks Bielecki, Katarzyna Orzol, Magdalena Bakun, Matylda Macias, Maria Kawalec, Karolina Bogusz, Katarzyna Misztal, Aleksandra Szybinska, Shiwani Kumari, Ewa Liszewska, Katarzyna Machnicka, Roberto Pagano, Szymon Jaworski, Marcelina Firkowska, Malgorzata Urbanska, Jacek Jaworski
    Academic press:
    Developmental Cell (rok: 2024, ), Wydawca: Cell Press
    Status:
    Submitted
    DOI:
    brak - link to the publication

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