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Role of proteasome in the regulation of Gli protein activity by the Hedgehog pathway

2017/27/B/NZ3/01163

Keywords:

proteasome protein degradation Gli proteins Hedgehog pathway transcription regulation signaling

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction
  • NZ3_13: Developmental biology in animals

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Paweł Niewiadomski 

Number of co-investigators in the project: 4

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 2 253 500 PLN

Project start date (Y-m-d): 2018-07-26

Project end date (Y-m-d): 2022-11-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus
    Authors:
    Markiewicz Ł, Uśpieński T, Baran B, Niedziółka SM, Niewiadomski P.
    Academic press:
    Cellular Signalling (rok: 2021, tom: 80, strony: 109907), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2020.109907 - link to the publication
  2. The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway
    Authors:
    Uspienski T., Niewiadomski P.
    Academic press:
    Cells (rok: 2024, tom: 6, strony: 1496), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells13171496 - link to the publication
  3. Targeting of SET/I2PP2A oncoprotein inhibits Gli1 transcription revealing a new modulator of Hedgehog signaling
    Authors:
    Serifi I, Besta S, Karetsou Z, Giardoglou P, Beis D, Niewiadomski P, Papamarcaki T.
    Academic press:
    Scientific Reports (rok: 2021, tom: 6, strony: 93440), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-93440-0 - link to the publication
  1. Proteasomal Regulation of Gli Proteins
    Authors:
    Uśpieński T, Niewiadomski P
    Conference:
    FEBS Congress 2019 (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 43652
    Status:
    Published
  2. Proteasomal Regulation of Gli Proteins
    Authors:
    Uśpieński T, Niewiadomski P
    Conference:
    Young Scientists Conference on Molecular and Cell Biology (rok: 2019, ), Wydawca: IIMCB
    Data:
    konferencja 43566
    Status:
    Published

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