Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Interdisciplinary view on activity of coumarins on the central nervous system - behavioral, analytical and mode of action studies

2017/27/B/NZ4/00917

Keywords:

coumarin furanocoumarins behavioral effects neurotransmitters level chromatography

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krystyna Skalicka-Woźniak 

Number of co-investigators in the project: 7

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 770 240 PLN

Project start date (Y-m-d): 2018-08-22

Project end date (Y-m-d): 2023-02-21

Project duration:: 54 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic–clonic seizure model: an isobolographic transformation
    Authors:
    Jarogniew J Łuszczki, Hubert Bojar, Katarzyna Jankiewicz, Magdalena Florek-Łuszczki, Jarosław Chmielewski, Krystyna Skalicka-Woźniak
    Academic press:
    Pharmacological Reports (rok: 2023, tom: 75(6), strony: 1533-1543), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-023-00532-x - link to the publication
  2. Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model—An Isobolographic Transformation
    Authors:
    Jarogniew J. Łuszczki , Hubert Bojar, Agnieszka Góralczyk, Krystyna Skalicka-Woźniak
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(2), strony: 1395), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24021395 - link to the publication
  3. Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock‑induced seizure model: an isobolographic transformation
    Authors:
    Jarogniew J. Łuszczki, Ewelina Kochman‑Moskal, Hubert Bojar, Magdalena Florek‑Łuszczki, Krystyna Skalicka‑Woźniak
    Academic press:
    Pharmacological Reports (rok: 2023, tom: 76(1), strony: 216-222), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-023-00555-4 - link to the publication
  4. Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on Behavioral and Neurochemical Sex Differences
    Authors:
    Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Woźniak *, Barbara Budzyńska
    Academic press:
    Molecules (rok: 2022, tom: 27(4), strony: 1179), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27041179 - link to the publication
  5. Neuropsychopharmacological profiling of scoparone in mice
    Authors:
    Joanna Kowalczyk, Barbara Budzyńska, Łukasz Kurach, Daniele Pellegata, Nesrine S. El Sayed, Jürg Gertsch, Krystyna Skalicka‑Woźniak
    Academic press:
    Scientific Reports (rok: 2022, tom: 12(1), strony: 822), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-04741-3. - link to the publication

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