Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Small-molecular chemical probes impairing Spire/FMN2 interaction as tools for the deconvolution of the role of the complex in normal and malignant cells - design, synthesis and structural characteristics

2017/27/N/ST5/01405

Keywords:

actin Spire FMN2 molecular probes tumors pharmacophore

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Radosław Kitel 

Number of co-investigators in the project: 3

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 139 400 PLN

Project start date (Y-m-d): 2018-09-03

Project end date (Y-m-d): 2022-01-02

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Drukarka laserowa (1 000 PLN)
  2. Dyski Twarde (749 PLN)
  3. Komputer - laptop (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Discovery of inhibitory fragments that selectively target Spire2-FMN2 interaction
    Authors:
    Radoslaw Kitel, Ewa Surmiak, Justyna Kalinowska-Tluscik, Przemyslaw Golik, Miroslawa Czub, Wiktor Uzar, Mariusz Madej, Grzegorz Dubin, Tad A. Holak
    Academic press:
    Journal of Medicinal Chemistry (rok: 2023, ), Wydawca: ACS Publications
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Analysis tools for single‑monomer measurements of self‑assembly processes
    Authors:
    Maria Hoyer, Alvaro H. Crevenna, Radoslaw Kitel, Kherim Willems , Miroslawa Czub, Grzegorz Dubin, Pol Van Dorpe, Tad A. Holak, Don C. Lamb
    Academic press:
    Scientific Reports (rok: 2022, tom: 12(1), strony: 4682), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-022-08245-6 - link to the publication

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