Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Impact of indoxyl sulfate on disturbances of bone homeostasis

2017/27/N/NZ4/00033

Keywords:

indoksyl sulfate chronic kidney disease bone metabolism biomechanical testing

Descriptors:

  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Karbowska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2018-08-10

Project end date (Y-m-d): 2022-08-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. Dose‑dependent exposure to indoxyl sulfate alters AHR signaling, sirtuins gene expression, oxidative DNA damage, and bone mineral status in rats
    Authors:
    Malgorzata Karbowska, Krystyna Pawlak, Beata Sieklucka, Tomasz Domaniewski, Urszula Lebkowska, Radoslaw Zawadzki & Dariusz Pawlak
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, 2583 (2024), strony: 45670), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-53164-3 - link to the publication
  1. CHRONIC EXPOSURE TO INDOXYL SULFATE CHANGES BONE PROPERTIES AND EXPRESSION OF SIRT2, SIRT3, AND SIRT7 GENES
    Authors:
    Malgorzata Karbowska, Beata Sieklucka, Tomasz Domaniewski, Malgorzata Galazyn-Sidorczuk, Krystyna Pawlak, Dariusz Pawlak
    Conference:
    58th ERA EDTA Virtual Congress 2021 in Berlin (rok: 2021, ), Wydawca: Oxford University Press, Nephrology Dialysis Transplantation, Volume 36, Issue Supplement_1, May 2021, gfab086.002
    Data:
    konferencja 05.-08.06.2021.
    Status:
    Published
  2. The effect of chronic exposure to indoxyl sulfate on geometric, densitometric and morphometric parameters of bones in animal model
    Authors:
    Karbowska M., Sieklucka B., Kaminski T., Mor A., Lipowicz P., Zawadzki R., Pawlak K., Pawlak D.
    Conference:
    ISN World Congress of Nephrology (WCN), Melbourne, Australia, (rok: 2019, ), Wydawca: Official Journal of the International Society of Nephrology, Elsevier
    Data:
    konferencja 12-15.04.19.
    Status:
    Published

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