Projects funded by the NCN
Global and local chromatin reorganisation in cellular response to DNA double-strand breaks, investigated with super-resolution fluorescence microscopy (dSTORM/SMLM) and fluorescence resonance energy transfer (FLIM/FRET)
2017/27/B/NZ3/01065
Keywords:
DNA DNA repair double-strand DNA breaks single-strand DNA breaks chromatin reorganisation superresolution microscopy single molecule localisation microscopy (SMLM) direct stochastic optical reconstruction microscopy (dSTORM) fluorescence lifetime microscopy (FLIM) Förster Resonance Energy Transfer (FRET) FLIM/FRET
Descriptors:
- NZ3_1: Cell biology
- NZ1_3: Biophysics
- NZ2_5: Cell genetics
Panel:
NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution :
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: OPUS 14 - announced on 2017-09-15
Amount awarded: 1 642 400 PLN
Project start date (Y-m-d): 2018-07-26
Project end date (Y-m-d): 2023-07-25
Project duration:: 60 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Fluorescence lifetime imaging reveals protein crowding in DNA repair fociAuthors:Levchenko, S; Dobrucki, JAcademic press:Proceedings of the National Academy of Sciences of the USA , Wydawca: US National Academy of SciencesStatus:SubmittedDOI:Brak - link to the publication
- STRIDE-a fluorescence method for direct, specific in situ detection of individual single- or double-strand DNA breaks in fixed cellsAuthors:Kordon, MM; Zarebski, M; Solarczyk, K; Ma, H; Pederson, T; Dobrucki, JAcademic press:Nucleic Acids Research (rok: 2020, tom: 48(3), strony: e14), Wydawca: Oxford AcademicStatus:PublishedDOI:10.1093/nar/gkz1118 - link to the publication
- Translocation of chromatin proteins to nucleoli-The influence of protein dynamics on post-fixation localizationAuthors:Zarębski M, Bosire R, Wesołowska J, Szelest O, Eatmann A, Jasińska-Konior K, Kepp O, Kroemer G, Szabo G, Dobrucki JW.Academic press:Cytometry Part A (rok: 2021, tom: 99(12), strony: 1230-1239), Wydawca: WileyStatus:PublishedDOI:10.1002/cyto.a.24464 - link to the publication