Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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A search for mechanism of anticancer properities of vitamin C; possible link between epigenetic DNA modyfications and vitamin C (ascorbate) oral supplementation: in vivo study

2017/27/B/NZ7/01487

Keywords:

Vitamin C epigenetics active DNA demethylation prostate cancer chronic lymphocytic leukemia biomarkers

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_3: Physical culture and health promotion

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Oliński 

Number of co-investigators in the project: 16

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 2 907 000 PLN

Project start date (Y-m-d): 2018-10-08

Project end date (Y-m-d): 2023-10-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (14)
  • Book publications / chapters in book publications (3)
  1. 5-Formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively
    Authors:
    Daniel Gackowski, Maciej Gawronski, Cassandra Kerr, Tomas Radivoyevitch, Ewelina Zarakowska, Marta Starczak, Abdulkadir Abakir, Alexey Ruzov, Jaroslaw P. Maciejewski, Ryszard Olinski
    Academic press:
    Haematologica (rok: 2020, tom: 105(5), strony: e213-e215), Wydawca: Ferrata Storti Foundation
    Status:
    Published
    DOI:
    10.3324/haematol.2019.224030 - link to the publication
  2. Unprecedentedly High Level of Intracellular Vitamin C and DNA Epigenetic Marks in Prostate: Relevant for Male Fertility?
    Authors:
    Jolanta Guz, Ewelina Zarakowska, Pawel Mijewski, Aleksandra Wasilow, Justyna Szpotan, Marek Foksinski, Bartosz Brzoszczyk, Daniel Gackowski, Piotr Jarzemski, Ryszard Olinski
    Academic press:
    Cell Physiol Biochem (rok: 2023, tom: 57(4), strony: 200-211), Wydawca: CELL PHYSIOL BIOCHEM PRESS GMBH & CO , Herzogstr. 85, Düsseldorf, Germany, 40215
    Status:
    Published
    DOI:
    10.33594/000000638 - link to the publication
  3. The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment
    Authors:
    Mateusz Ga˛bka, Paulina Dałek, Magdalena Przybyło, Daniel Gackowski, Ryszard Oliński and Marek Langner
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45672), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10112964 - link to the publication
  4. Intracellular ascorbate is a safe-guard and/or reservoir for plasma vitamin C in prostate cancer patients undergoing radiotherapy
    Authors:
    Ewelina Zarakowska, Jolanta Guz, Pawel Mijewski, Aleksandra Wasilow, Jakub Wozniak, Krzysztof Roszkowski, Marek Foksinski, Daniel Gackowski, Ryszard Olinski
    Academic press:
    Free Radical Biology and Medicine (rok: 2023, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.freeradbiomed.2023.11.024 - link to the publication
  5. Genomic uracil and aberrant profile of demethylation intermediates in epigenetics and hematologic malignancies.
    Authors:
    Oliński Ryszard, Slupphaug G., Foksiński Marek, Krokan H.E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, 4212, strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084212 - link to the publication
  6. Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
    Authors:
    Guan Y, Greenberg EF, Hasipek M, Chen S, Liu X, Kerr CM, Gackowski D, Zarakowska E, Radivoyevitch T, Gu X, Willard B, Visconte V, Makishima H, Nazha A, Mukherji M, Sekeres MA, Saunthararajah Y, Oliński R, Xu M, Maciejewski JP, Jha BK
    Academic press:
    COMMUNICATIONS BIOLOGY (rok: 2020, tom: 3, strony: 493), Wydawca: NATURE PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.1038/s42003-020-01220-9 - link to the publication
  1. DNA demethylation products in leukocytes of prostate cancer patients.
    Authors:
    Zarakowska, E., Guz, J., Mijewski, P., Wasilow, A., Szpila, A., Gackowski, D., Olinski, R.
    Conference:
    1st Epigenetics Society International Meeting "Epigenetics of Disease and Development" (rok: 2023, ), Wydawca: Frontiers
    Data:
    konferencja October 12-14 2023
    Status:
    Published
  2. Role of N6-methyladenine and its derivatives - potential relationships with leukemia development
    Authors:
    Marta Starczak, Maciej Gawroński, Aleksandra Wasilów, Aleksandra Skalska-Bugała, Paweł Mijewski, Patrycja Bagińska, Fabian Leśniewski, Jarosław Czyż, Daniel Gackowski, Ryszard Oliński
    Conference:
    Clinical Epigenetics International Conference (CLEPIC 2023) (rok: 2023, ), Wydawca: International Society for Molecular and Clinical Epigenetics
    Data:
    konferencja 24-26 maj 2023
    Status:
    Published
  3. Radiotherapy effect on the level of urinary active demethylation products of 5-methylcytosine in patients with prostate cancer
    Authors:
    Aleksandra Skalska-Bugała, Fabian Leśniewski, Rafał Różalski, Agnieszka Siomek-Górecka, Marta Starczak, Aleksandra Wasilów, Patrycja Bagińska, Paweł Mijewski, Ryszard Oliński
    Conference:
    Clinical Epigenetics International Conference (CLEPIC 2023) (rok: 2023, ), Wydawca: International Society for Molecular and Clinical Epigenetics
    Data:
    konferencja 24-26 maj 2023
    Status:
    Published
  4. DNA demethylation meodifications and intracellular vitamin C level inside both healthy cells and cancerous cells from prostate tissues
    Authors:
    Paweł Mijewski, Ewelina Zarakowska, Aleksandra Wasilów, Justyna Szpotan, Jolanta Guz, Marta Starczak, Aleksandra Skalska-Bugała, Patrycja Bagińska, Fabian Leśniewski, Daniel Gackowski, Marek Foksiński, Ryszard Oliński
    Conference:
    Clinical Epigenetics International Conference (CLEPIC 2023) (rok: 2023, ), Wydawca: International Society for Molecular and Clinical Epigenetics
    Data:
    konferencja 24-26 maj 2023
    Status:
    Published
  5. Effects of vitamin C supplementation on epigenetic DNA modifications levels in patients with chronic lymphocytic leukemia
    Authors:
    A. Wasilow, M. Gawronski, M. Starczak, J. Szpotan, M. Kruszewski, A. Jachalska, P. Mijewski, L. Szukalski, A. Szukalska, K. Kaczorowska, A. SkalskaBugala, P. Baginska, A. Labejszo, J. Czyz, D. Gackowski, R. Olinski
    Conference:
    IUBMB–FEBS–PABMB Congress in Lisbon (rok: 2022, ), Wydawca: FEBS Open Bio, Volume 12 Supplement 1 July 2022
    Data:
    konferencja 9-14 July, 2022
    Status:
    Published
  6. The expression of proteins involved in epigenetic processes in chronic lymphocytic leukemia (CLL)
    Authors:
    A. Wasilow, P. Baginska, L. Gackowska, A. Wolowiec, M. Gawronski, M. Starczak, P. Mijewski, A. Skalska-Bugala, F. Lesniewski, J. Czyz, D. Gackowski, R. Olinsk
    Conference:
    1st Epigenetics Society International Meeting "Epigenetics of Disease and Development" (rok: 2023, ), Wydawca: Frontiers
    Data:
    konferencja October 12-14 2023
    Status:
    Published
  7. Vitamin C supplementation stimulates DNA demethylation in patients with chronic lymphocytic leukemia
    Authors:
    Aleksandra Wasilów, Maciej Gawroński, Marta Starczak, Paweł Mijewski, Aleksandra Skalska-Bugała, Patrycja Bagińska, Daniel Gackowski, Ryszard Oliński
    Conference:
    Max Planck Freiburg 6th Epigenetics Meeting (rok: 2022, ), Wydawca: Max Planck Institute of Immunobiology and Epigenetics, Freiburg
    Data:
    konferencja 30 November-2 December 2022
    Status:
    Published
  8. Effect of oral vitamin C supplementation during radiotherapy on the urinary levels of the active demethylation products of 5-methylcytosine in prostate cancer patients
    Authors:
    Fabian Leśniewski, Aleksandra Skalska-Bugała, Rafał Różalski, Agnieszka Siomek-Górecka, Marta Starczak, Paweł Mijewski, Aleksandra Wasilów, Patrycja Bagińska, Ryszard Oliński
    Conference:
    Clinical Epigenetics International Conference (CLEPIC 2023) (rok: 2023, ), Wydawca: International Society for Molecular and Clinical Epigenetics
    Data:
    konferencja 24-26 maj 2023
    Status:
    Published
  9. The potential sources of changes in DNA methylation profile in chronic lymphocytic leukemia
    Authors:
    Aleksandra Wasilów, Paweł Mijewski, Marta Starczak, Maciej Gawroński, Ewelina Zarakowska, Jolanta Guz, Aleksandra Skalska-Bugała, Patrycja Bagińska, Fabian Leśniewski, Daniel Gackowski, Ryszard Oliński
    Conference:
    Clinical Epigenetics International Conference (CLEPIC 2023) (rok: 2023, ), Wydawca: International Society for Molecular and Clinical Epigenetics
    Data:
    konferencja 24-26 maj 2023
    Status:
    Published
  10. N6-methyl-2'-deoxyadenosine and its derivatives in human DNA
    Authors:
    Starczak, M., Gawronski, M., Wasilow, A., Skalska-Bugala, A., Mijewski, P., Baginska, P., Lesniewski, F., Czyz, J., Gackowski, D., Olinski, R.
    Conference:
    1st Epigenetics Society International Meeting "Epigenetics of Disease and Development" (rok: 2023, ), Wydawca: Frontiers
    Data:
    konferencja October 12-14 2023
    Status:
    Published
  11. DNA demethylation modifications and intracellular vitamin C level inside prostate tissues
    Authors:
    Mijewski, P., Zarakowska, E., Wasilów, A., Szpotan, J., Gackowski, D., Foksiński, M., Oliński, R.
    Conference:
    1st Epigenetics Society International Meeting "Epigenetics of Disease and Development" (rok: 2023, ), Wydawca: Frontiers
    Data:
    konferencja October 12-14 2023
    Status:
    Published
  12. Vitamin C concentration inside both healthy cells and cancerous cells from prostate tissue
    Authors:
    P. Mijewski, A. Wasilow, E. Zarakowska, J. Szpotan, P. Baginska, D. Gackowski, M. Foksinski, R. Olinski
    Conference:
    IUBMB–FEBS–PABMB Congress in Lisbon (rok: 2022, ), Wydawca: FEBS Open Bio, Volume 12 Supplement 1 July 2022
    Data:
    konferencja 9-14 July, 2022
    Status:
    Published
  13. Impact of vitamin C supplementation on the epigenetic modifications in DNA and mRNA expression of vitamin C transporter genes in chronic lymphocytic leukemia
    Authors:
    Ewelina Zarakowska, Jolanta Guz, Paweł Mijewski, Aleksandra Wasilów, Anna Szpila, Daniel Gackowski, Ryszard Oliński
    Conference:
    XXVIIth Biochemistry Congress of Slovak and Czech Societies for Biochemistry and Molecular Biology with cooperation of Hungarian and Ukrainian Biochemical Societies. FEBS3+ Meeting. "50 years of Recombinant DNA - Past, Present, Future" (rok: 2023, ), Wydawca: Slovak Society for Biochemistry and Molecular Biology
    Data:
    konferencja 10-09-2023 - 13-09-2023
    Status:
    Published
  14. The effect of radiotherapy on the level of intracellular vitamin C in patients with prostate cancer
    Authors:
    Paweł Mijewski, Ewelina Zarakowska, Aleksandra Wasilów, Daniel Gackowski, Marek Foksiński, Ryszard Oliński
    Conference:
    XXVIIth Biochemistry Congress of Slovak and Czech Societies for Biochemistry and Molecular Biology with cooperation of Hungarian and Ukrainian Biochemical Societies. FEBS3+ Meeting. "50 years of Recombinant DNA - Past, Present, Future" (rok: 2023, ), Wydawca: Slovak Society for Biochemistry and Molecular Biology
    Data:
    konferencja 10-09-2023 - 13-09-2023
    Status:
    Published
  1. Preparation of Internal Standards for 2D-UPLC-MS/MS Quantification of Noncanonical DNA Bases
    Authors:
    Marta Starczak, Aleksandra Skalska, Rafal Rozalski, Ryszard Olinski, and Daniel Gackowski
    Book:
    DNA Modifications: Methods and Protocols, Methods in Molecular Biology (rok: 2021, tom: vol 2198, strony: 123-136), Wydawca: Humana, New York, NY
    Status:
    Published
  2. Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS)
    Authors:
    Marta Starczak, Maciej Gawronski, Ryszard Olinski, and Daniel Gackowski
    Book:
    DNA Modifications: Methods and Protocols, Methods in Molecular Biology (rok: 2021, tom: vol 2198, strony: 91-108), Wydawca: Humana, New York, NY
    Status:
    Published
  3. MS Analysis of DNA Modifications in Urinary/Body Fluids
    Authors:
    Aleksandra SkalskaAgnieszka Siomek-GoreckaRyszard OlinskiRafal Rozalski
    Book:
    DNA Modifications: Methods and Protocols, Methods in Molecular Biology (rok: 2021, tom: vol 2198, strony: 109-122), Wydawca: Humana, New York, NY
    Status:
    Published

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