Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of Fam46C in B cell phisiology

2017/27/B/NZ2/01234

Keywords:

mRNA polyadenylation Immunology B-cells FAM46C multiple myeloma

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_3: Proteomics
  • NZ2_6: Immunogenetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Seweryn Mroczek 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 798 200 PLN

Project start date (Y-m-d): 2018-10-02

Project end date (Y-m-d): 2022-10-01

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputery z oprogramowaniem (12 000 PLN)
  2. Aparat do transferu białek (BioRad; Trans-Blot SD Semi-Dry Transfer Cell) z dedykowanym zasilaczem.
  3. Mastercycler Nexus GSX1.
  4. Kołyska laboratoryjna PROBLOT 25XL.
  5. Maszyna PCR (The Biometra T3000 lub podobna) (50 000 PLN)
  6. Rozdrabniacz do tkanek (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
    Authors:
    Aleksandra Bilska, Monika Kusio-Kobiałka, Paweł S. Krawczyk, Olga Gewartowska, Bartosz Tarkowski, Kamil Kobyłecki, Dominika Nowis, Jakub Golab, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski, Seweryn Mroczek
    Academic press:
    Nature Communications (rok: 2021, tom: Brak, strony: Brak), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41467-020-15835-3 - link to the publication
  2. Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
    Authors:
    Olga Gewartowska, Goretti Aranaz Novaliches, Paweł S Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej Dziembowski
    Academic press:
    Cell Reports (rok: 2021, tom: 35, strony: 109015), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2021.109015 - link to the publication
  3. Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism
    Authors:
    Zbigniew Warkocki, Vladyslava Liudkovska, Olga Gewartowska, Seweryn Mroczek, Andrzej Dziembowski
    Academic press:
    Philosophical Transactions of the Royal Society B: Biological Sciences (rok: 2018, tom: 373, strony: 45307), Wydawca: rstb.royalsocietypublishing.org
    Status:
    Published
    DOI:
    10.1098/rstb.2018.0162 - link to the publication
  4. TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animala
    Authors:
    Vladyslava Liudkovska, Paweł S Krawczyk, Aleksandra Brouze, Natalia Gumińska, Tomasz Wegierski, Dominik Cysewski, Zuzanna Mackiewicz, Jonathan J Ewbank, Krzysztof Drabikowski, Seweryn Mroczek, Andrzej Dziembowski
    Academic press:
    Science Advances (rok: 2022, tom: 8(46), strony: 45312), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.add9468 - link to the publication

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