Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Phenotype of macrophages activated in vitro with biofilm bacteria isolated from cystic fibrosis lung infections. Evaluation of a regulatory and antibcterial role of M1 and M2 "trained" macrophages in inflammation associated with biofilm infections.

2017/27/B/NZ6/01772

Keywords:

biofilm cystic fibrosis chronic inflammation neutrophils trained macrophaages P. aeruginosa S. aureus innate immunity

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_4: Bacteriology
  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Marcinkiewicz 

Number of co-investigators in the project: 20

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 638 200 PLN

Project start date (Y-m-d): 2018-07-13

Project end date (Y-m-d): 2023-07-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop (7 499 PLN)
  2. Mini vortex laboratoryjny.
  3. Mikroskop odwrócony (40 000 PLN)
  4. Chemiluminometr (46 000 PLN)
  5. Dewary z wyposażeniem do przechowywania i transportu komórek w ciekłym azocie (20 000 PLN)
  6. Komora Laminarna (65 000 PLN)
  7. Komputer z oprogramowaniem (10 000 PLN)
  8. Lampa UV statywowa.
  9. Mini wirówka.
  10. Spektrofotometr (Nanodrop) (30 000 PLN)
  11. Komputer z oprogramowaniem.
  12. Laptop.
  13. Monitor (850 PLN)
  14. Wytrząsarka do mikropłytek i probówek (5 000 PLN)
  15. Laptop (7 312 PLN)
  16. Mini vortex laboratoryjny (1 000 PLN)
  17. Stacja do bezpiecznego usuwania nadsączy z hodowli. (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Pseudomonas aeruginosa biofilm is a potent inducer of phagocyte hyperinflammation.
    Authors:
    Ciszek-Lenda M, Strus M, Walczewska M, Majka G, Machul-Żwirbla A, Mikołajczyk D, Górska S, Gamian A, Chain B, Marcinkiewicz J
    Academic press:
    Inflammation Research (rok: 2019, tom: 68(5), strony: 397-413), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-019-01227-x - link to the publication
  2. Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages.
    Authors:
    Marta Ciszek-Lenda, Grzegorz Majka, Maciej Suski, Maria Walczewska, Sabina Górska, Edyta Golińska, Angelika Fedor, Andrzej Gamian, Rafał Olszanecki, Magdalena Strus, Janusz Marcinkiewicz
    Academic press:
    Inflammation Reaserch (rok: 2023, tom: 72(6), strony: 1275-1289), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-023-01743-x. - link to the publication
  3. Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6
    Authors:
    Grzegorz Majka, Henryk Mazurek , Magdalena Strus , Marta Ciszek-Lenda , Rafał Szatanek , Agnieszka Pac , Edyta Golińska , Janusz Marcinkiewicz
    Academic press:
    Clinical and Experimental Immunology (rok: 2021, tom: 205 (3), strony: 391-405), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/cei.13624 - link to the publication
  4. Cytokines as predictors of COVID-19 severity: evidence from a meta-analysis. Authors' reply
    Authors:
    Marcinkiewicz J, Majka G
    Academic press:
    Polish Archives of Internal Medicine (rok: 2021, tom: 131, strony: bd), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.15794 - link to the publication
  5. Are patients with lung cystic fibrosis at increased risk of severe and fatal COVID-19? Interleukin 6 as a predictor of COVID-19 outcomes.
    Authors:
    Marcinkiewicz J, Mazurek H, Majka G, Chain B
    Academic press:
    Polish Archives of Internal Medicine (rok: 2020, tom: 130, strony: 919-920), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.15630 - link to the publication

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