Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Development of the novel experimental gene therapy approach for glaucoma treatment - focusing on the role of RNA-binding proteins

2017/26/D/NZ4/00473

Keywords:

glaucoma gene therapy RNA-binding proteins neuroprotection

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Adrian Smędowski 

Number of co-investigators in the project: 3

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 1 121 620 PLN

Project start date (Y-m-d): 2018-04-12

Project end date (Y-m-d): 2021-12-11

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do elektroforezy i transferu do Western blot (15 000 PLN)
  2. Mikroskop operacyjny z światłem koaksjalnym (40 000 PLN)
  3. Aparatura do badań elektroretinograficznych "Celeris" (250 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function
    Authors:
    Smedowski Adrian, Akhtar Saeed, Liu Xiaonan, Pietrucha-Dutczak Marita, Podracka Lucia, Toropainen Elisa, Alkanaan Alkanaan, Ruponen Marika, Urtti Arto, Varjosalo Markku, Kaarniranta Kai, Lewin-Kowalik Joanna.
    Academic press:
    Acta Ophthalmologica (rok: 2019, tom: 10, strony: 45301), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/aos.14272 - link to the publication
  2. The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration
    Authors:
    Marita Pietrucha-Dutczak, Marialaura Amadio, Stefano Govoni, Joanna Lewin-Kowalik, Adrian Smedowski
    Academic press:
    Frontiers in Neuroscience (rok: 2018, tom: 12, strony: 834), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnins.2018.00834 - link to the publication
  3. Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells
    Authors:
    Anna Pacwa, Joanna Machowicz, Saeed Akhtar, Piotr Rodak, Xiaonan Liu, Marita Pietrucha-Dutczak, Joanna Lewin-Kowalik, Marialaura Amadio and Adrian Smedowski
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2023, tom: 17, strony: ), Wydawca: Frontiers
    Status:
    Accepted for publication
    DOI:
    10.3389/fncel.2023.1131356 - link to the publication

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