Projects funded by the NCN
MMP-9 in shaping of synaptic plasticity: An individual dendritic spine approach
2017/26/A/NZ3/00379
Keywords:
Excitatory synapses extracellular matrix BDNF plasticity organotypic culture
Descriptors:
- NZ3_6:
- NZ3_5:
Panel:
NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution :
Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 7
Call: MAESTRO 9 - announced on 2017-06-14
Amount awarded: 3 907 100 PLN
Project start date (Y-m-d): 2018-03-22
Project end date (Y-m-d): 2025-07-21
Project duration:: 88 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- BDNF-driven synaptic plasticity requires autocrine Matrix Metalloproteinase-9 activityAuthors:Diana Legutko, Lukasz Bijoch, Grzegorz Olszak, Bożena Kuźniewska, Katarzyna Kalita, Ryohei Yasuda, Leszek Kaczmarek, Piotr MichalukAcademic press:Science Advances (rok: 2025, tom: 11, strony: eadx2369), Wydawca: AAASStatus:PublishedDOI:10.1126/sciadv.adx2369 - link to the publication
- Inhibition of matrix metalloproteinase 9 activity promotes synaptogenesis in the hippocampusAuthors:Ahmad Salamian, Diana Legutko, Klaudia Nowicka, Bogna Badyra, Paulina Kaźmierska-Grębowska, Bartosz Caban, Tomasz Kowalczyk, Leszek Kaczmarek, Anna BerounAcademic press:Cerebral Cortex (rok: 2021, tom: 31, strony: 3804-3819 oraz 3161-3163), Wydawca: OXFORD UNIV PRESS INCStatus:PublishedDOI:10.1093/cercor/bhab105. - link to the publication