Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Heme and G-quadruplexes: an overlooked function of heme oxygenases?

2017/25/B/NZ3/00986

Keywords:

heme heme oxygenases G-quadruplexes genome stability replication stress oxidative stress

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction
  • NZ1_1: Molecular biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Alicja Józkowicz 

Number of co-investigators in the project: 7

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 465 800 PLN

Project start date (Y-m-d): 2018-02-07

Project end date (Y-m-d): 2022-02-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Nrf2 Sequesters Keap1 Preventing Podosome Disassembly: A Quintessential Duet Moonlights in Endothelium
    Authors:
    Kloska D, Kopacz A, Cysewski D, Aepfelbacher M, Dulak J,1 Jozkowicz A, Grochot-Przeczek A
    Academic press:
    Antioxid Redox Signal (rok: 2018, tom: 29, strony: 45679), Wydawca: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/ars.2018.7505 - link to the publication
  2. Heme oxygenase-1 protects cells from replication stress.
    Authors:
    1.Chudy P., Kochan J., Wawro M., Nguyen P., Gorczyca M., Varanko A., Retka A., Ghadei S.S., Napieralska E., Grochot-Przęczek A., Szade K., Berendes L.S., Park J., Sokołowski G., Yu Q., Józkowicz A., Nowak W.N., Krzeptowski W.
    Academic press:
    Redox Biology , Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.redox.2024.103247 - link to the publication
  3. Proximity ligation assay detection of protein–DNA interactions – is there a link between heme oxygenase-1 and G-quadruplexes?
    Authors:
    Krzeptowski W, Chudy P, Sokołowski G, Żukowska M, Kusienicka A, Seretny A, Kalita A, Czmoczek A, Gubała J, Baran S, Klóska D, Jez M, Stępniewski J, Szade K, Szade A, Anna Grochot-Przęczek A, Józkowicz A, Nowak WN
    Academic press:
    Antioxidants (rok: 2021, tom: 10, strony: 45679), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10010094 - link to the publication
  4. Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.
    Authors:
    Kloska D., Kopacz A., Piechota-Polanczyk A., Neumayer C., Huk I., Dulak J., Jozkowicz A., Grochot-Przeczek A.
    Academic press:
    Arch Biochem Biophys (rok: 2019, tom: 678, strony: 45670), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2019.108182 - link to the publication

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