Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Directed Evolution of Peptides Able to Dissolve Crystals of Calcium Pyrophosphate Dihydrate- a factor causing Calcium Pyrophosphate Deposition Disease.

2017/25/N/NZ7/00960

Keywords:

CPPD pseudogut chondrocalcinosis catalytic peptides phage display arthrisis

Descriptors:

  • ST5_23:
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Radosław Piast 

Number of co-investigators in the project: 2

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2018-01-24

Project end date (Y-m-d): 2021-06-23

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. cieplarka z opcją wytrząsania.
  2. Przedłużenie koncesji na oprogramowanie do dynamiki molekularnej Yasara (2 129 PLN)
  3. komputer ze specjalistycznym oprogramowaniem (5 000 PLN)
  4. autoklaw (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Small Cyclic Peptide for Pyrophosphate Dependent Ligation in Prebiotic Environments
    Authors:
    Piast, Radosław W., Maciej Garstka, Aleksandra Misicka, and Rafał M. Wieczorek
    Academic press:
    Life (rok: 2020, tom: 10, strony: 45303), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/life10070103 - link to the publication
  2. Phage display identified short peptide capable of hydrolyzing calcium pyrophosphate crystals - the etiological factor of chondrocalcinosis
    Authors:
    Radosław W. Piast , Rafał M. Wieczorek, Nicola Marzec, Maciej Garstka, Aleksandra Misicka
    Academic press:
    Molecules (rok: 2021, ), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Submitted
    DOI:
    brak - link to the publication

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