Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Prolidase as a stimulating factor of wound healing in experimental models of skin cells

2017/25/B/NZ7/02650

Keywords:

prolidase wound healing collagen EGFR

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Miltyk 

Number of co-investigators in the project: 6

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 728 020 PLN

Project start date (Y-m-d): 2018-05-07

Project end date (Y-m-d): 2022-05-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wound Maker.
  2. Zestaw do elektroforezy poziomy (2 szt.) (18 000 PLN)
  3. Licencja do programu SnapGene (7 000 PLN)
  4. Obiektyw do mikroskopu konfokalnego, powiększenie 100x (20 500 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Current Understanding of the Emerging Role of Prolidase in Cellular Metabolism.
    Authors:
    Misiura M, Miltyk W.
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21, strony: 5906-5926), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21165906. - link to the publication
  2. Extracellular prolidase (PEPD) induces anabolic processes through EGFR, ß1-integrin, and IGF-1R signaling pathways in an experimental model of wounded fibroblasts.
    Authors:
    Baszanowska Weronika, Misiura Magdalena, Ościłowska Ilona, Pałka Jerzy, Miltyk Wojciech.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 13), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020942 - link to the publication
  3. Development of an LC-MS Targeted Metabolomics Methodology to Study Proline Metabolism in Mammalian Cell Cultures
    Authors:
    Klupczynska A, Misiura M, Miltyk W, Oscilowska I, Palka J, Kokot ZJ, Matysiak J.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4639), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204639 - link to the publication
  4. Prolidase Stimulates Proliferation and Migration through Activation of the PI3K/Akt/mTOR Signaling Pathway in Human Keratinocytes.
    Authors:
    Misiura M, Baszanowska W, Ościłowska I, Pałka J, Miltyk W.
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21, strony: 9243), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239243 - link to the publication
  5. Proline-containing peptides - new insight and implications: a review.
    Authors:
    Misiura M, Miltyk W
    Academic press:
    Biofactors (rok: 2019, tom: -, strony: 10pp), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/biof.1554 - link to the publication
  6. Platelet-rich plasma promotes the proliferation of human keratinocytes via a progression of the cell cycle. A role of prolidase.
    Authors:
    agdalena, Guszczyn Tomasz, Ościłowska Ilona, Baszanowska Weronika, Pałka Jerzy, Miltyk Wojciech.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020936 - link to the publication
  7. Recombinant prolidase activates EGFR-dependent cell growth in an experimental model of inflammation in HaCaT keratinocytes. Implication for wound healing.
    Authors:
    Nizioł Magdalena, Ościłowska Ilona, Baszanowska Weronika, Pałka Jerzy, Besio Roberta, Forlino Antonella, Miltyk Wojciech.
    Academic press:
    FRONTIERS IN MOLECULAR BIOSCIENCES (rok: 2022, tom: 9, strony: 45304), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2022.869413 - link to the publication

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