Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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DNA methylation as a modulating factor of response to thiopurine drugs in patients with inflammatory bowel disease

2017/25/B/NZ5/02783

Keywords:

IBD Crohn's desease ulcerative colitis DNA methylation thiopurine drugs

Descriptors:

  • NZ5_7:
  • NZ5_5:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jarosław Mirosław Walkowiak 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 978 980 PLN

Project start date (Y-m-d): 2018-02-07

Project end date (Y-m-d): 2025-02-06

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (13)
  1. Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2
    Authors:
    Nowak JK, Adams AT, Kalla R, Lindstrøm JC, Vatn S, Bergemalm D, Keita ÅV, Gomollón F, Jahnsen J, Vatn MH, Ricanek P, Ostrowski J, Walkowiak J, Halfvarson J, Satsangi J.
    Academic press:
    Journal of Crohn's & colitis. (rok: 2022, tom: 16, strony: 1255-1268), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1093/ecco-jcc/jjac033. - link to the publication
  2. Waiting in the wings: RUNX3 reveals hidden depths of immune regulation with potential implications for inflammatory bowel disease.
    Authors:
    Dybska E, Adams AT, Duclaux-Loras R, Walkowiak J, Nowak JK.
    Academic press:
    Scandinavian journal of immunology (rok: 2021, tom: 93, strony: e13025), Wydawca: Universitetsforlaget
    Status:
    Published
    DOI:
    10.1111/sji.13025 - link to the publication
  3. Transcriptomic Context of RUNX3 Expression in Monocytes: A Cross-Sectional Analysis.
    Authors:
    Dybska E, Nowak JK, Walkowiak J.
    Academic press:
    Biomedicines (rok: 2023, tom: 11, strony: 1698), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines11061698 - link to the publication
  4. Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells.
    Authors:
    Nowak JK, Dworacka M, Gubaj N, Dossimov A, Dossimov Z, Walkowiak J.
    Academic press:
    Allergy, asthma, and clinical immunology (rok: 2021, tom: 17, strony: 82), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13223-021-00584-9 - link to the publication
  5. Ileal Lactase Expression Associates with Lactase Persistence Genotypes.
    Authors:
    Nowak JK, Dybska E, Dworacka M, Tsikhan N, Kononets V, Bermagambetova S, Walkowiak J.
    Academic press:
    Nutrients (rok: 2021, tom: 13, strony: 1340), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu13041340 - link to the publication
  6. Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease-A Multi-Centre Cross-Sectional Study
    Authors:
    Glapa-Nowak A, Szczepanik M, Kwiecień J, Szaflarska-Popławska A, Flak-Wancerz A, Iwańczak B, Osiecki M, Kierkuś J, Pytrus T, Lebensztejn D, Banasiewicz T, Banaszkiewicz A, Walkowiak J
    Academic press:
    Journal of Clinical Medicine (rok: 2020, tom: 9, strony: 3957), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9123957 - link to the publication
  7. Apolipoprotein E variants correlate with the clinical presentation of paediatric inflammatory bowel disease: A cross-sectional study
    Authors:
    Glapa-Nowak A, Szczepanik M, Iwańczak B, Kwiecień J, Szaflarska-Popławska AB, Grzybowska-Chlebowczyk U, Osiecki M, Dziekiewicz M, Stawarski A, Kierkuś J, Banasiewicz T, Banaszkiewicz A, Walkowiak J
    Academic press:
    World Journal of Gastroenterology (rok: 2021, tom: 27, strony: 1483-1496), Wydawca: Baishideng Publishing Group
    Status:
    Published
    DOI:
    10.3748/wjg.v27.i14.1483 - link to the publication
  8. HLA-DQA1*05 Associates with Extensive Ulcerative Colitis at Diagnosis: An Observational Study in Children.
    Authors:
    Nowak JK, Glapa-Nowak A, Banaszkiewicz A, Iwańczak B, Kwiecień J, Szaflarska- Popławska A, Grzybowska-Chlebowczyk U, Osiecki M, Kierkuś J, Hołubiec M, Chanaj- Kaczmarek J, Radzikowski A, Walkowiak J.
    Academic press:
    Genes (Basel) (rok: 2021, tom: 12, strony: 1934), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes12121934. - link to the publication
  9. Unexpected Actors in Inflammatory Bowel Disease Revealed by Machine Learning from Whole-Blood Transcriptomic Data
    Authors:
    Nowak JK, Szymańska CJ, Glapa-Nowak A, Duclaux-Loras R, Dybska E, Ostrowski J, Walkowiak J, Adams AT
    Academic press:
    Genes (Basel) (rok: 2022, tom: 13, strony: 1570), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13091570 - link to the publication
  10. Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease-A Polish Population - Based Study.
    Authors:
    Glapa-Nowak A, Szczepanik M, Banaszkiewicz A, Iwańczak B, Kwiecień J, Szaflarska-Popławska A, Grzybowska-Chlebowczyk U, Osiecki M, Kierkuś J, Banasiuk M, Banasiewicz T, Madsen J, Walkowiak J.
    Academic press:
    Children (Basel) (rok: 2021, tom: 8, strony: 946), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/children8110946 - link to the publication
  11. Immune cell-specific smoking-related expression characteristics are revealed by re-analysis of transcriptomes from the CEDAR cohort.
    Authors:
    Nowak JK, Dybska E, Adams AT, Walkowiak J.
    Academic press:
    Central European Journal of Immunology (rok: 2022, tom: 47, strony: 246-259), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/ceji.2022.120618 - link to the publication
  12. Methylation of RUNX3 Promoter 2 in the Whole Blood of Children with Ulcerative Colitis
    Authors:
    Dybska E, Nowak JK, Banaszkiewicz A, Szaflarska-Popławska A, Kierkuś J, Kwiecień J, Grzybowska-Chlebowczyk U, Walkowiak J.
    Academic press:
    Genes (Basel). (rok: 2022, tom: 13, strony: 1568), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13091568 - link to the publication
  13. Differential correlation network analysis of rectal transcriptomes reveals cystic fibrosis-related disturbance
    Authors:
    Nowak JK, Szymańska CJ, Walkowiak J.
    Academic press:
    Pharmacogenomics (rok: 2022, tom: 23, strony: 339-344), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.2217/pgs-2021-0138 - link to the publication

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